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Cytodiagnostics > Lymph node analysis > Flashcards

Lymph node analysis Flashcards

1
Q

In cases of generalized lymphadenopathy, which LN are best to aspirate?

A

popliteal and prescapular LN

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2
Q

What is the makeup of a normal LN?

A

75-90% small lymphocytes

5-10% intermediate

<5% lymphoblasts

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3
Q

What are the possible differentials for lymph node enlargement?

A

LN hyperplasia

lymphadenitis

lymphoma

metastatic neoplasia

edema

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4
Q

Classify this LN aspirate.

A

Reactive LN hyperplasia:

increase (not >10-20%) # intermediate & large lymphs

plasma cells w/ mott cells (contain IG)

can see low # mast cells

lymphoglandular bodies (pieces of basophilic cytoplasm from lysed lymphocytes)

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5
Q

Classify this LN aspirate.

What is the arrow pointing to?

A

Reactive LN hyperplasia

lymphoglandular bodies

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6
Q

Lymphadenitis is characterized by what?

A

Increase in the number of inflammatory cells:

Neutrophilic >5% NT

Eosinophilic >3% eos

Pyogranulomatous (significant macrophages)

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7
Q

With which neoplasms, could an eosinophilic inflammation in a LN aspirate been seen?

A

mast cell

T-cell lymphoma

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8
Q

When can a diagnosis of lymphoma be reliably made?

A

>50% lymphoblasts

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9
Q

What neoplasm is associated with hypercalcemia of malignancy originating from the LN?

A

T-cell lymphoma

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10
Q

Hyperglobulinemia is often seen with which cancers?

A

myelomas and B-cell tumors

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11
Q

What is the most common form of lymphoma in dogs?

What type of cells characterizes the neoplasia?

A

multicentric lymphoma

lymphoblast cells

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12
Q

Classify this LN aspirate.

What is the arrow pointing to?

A

Neoplastic, lymphoma

indistinct nucleoli (a common characteristic of multicentric lymphoma)

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13
Q

Why should you collect a LN aspirate before you administer steroids?

A

lymphoblastic cells are more sensitive to the cytotoxic effects of steroids

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14
Q

Peripheral multicentric lymphoma is common in the cat. T/F?

A

FALSE (rare)

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15
Q

Why is diagnosing lymphoma in a cat harder than in a dog?

A

lymphoma of small, well diff lymphocytes

most lymphomas do not involve the peripheral LN (more often than not just hyperplasia)

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16
Q

What is the most common form of lymphoma in the cat?

A

alimentary

17
Q

What are the three most common forms of GI lymphoma?

A

small cell well-diff lymphoma (hard to ddx from IBD, older cats)

Large Granular lymphoma (cytotoxic T-cell or NK cells)

Large cell- typically B-cell (masses in colon)

18
Q

The following aspirates were obtained from the GI of a feline. Likely DDX? How do you know?

A

Large granular lymphoma

focal granules in the cytoplasm

19
Q

A 10 year old feline presents for enlarged cervical LN in chain. The cytology is shown below. What is the likely DX and prognosis? What is the cell type characteristic of this disease seen in the cytology? Can it be reliably dx on cytology?

A

Hodgkin’s - like lymphoma

Good prognosis with sx

Reed-sternberg-like cells ( multi-nucleated cells)

Need histopath

20
Q

A 1 year old feline presents for multiple enlarged LN. The cytology indicates an increased number of lymphoblastic cells. What is the likely dx? Cause? Prognosis? Can it be dx on cytology?

A

Distinctive peripheral LN hyperplasia

idiopathic

lymphadenopathy regresses in 1-17 weeks

Need histologic dx

21
Q

Is small cell GI lymphoma associated with FeLV + felines?

A

NO***

22
Q

In which cats do we typically see FeLV associated lymphoma? What type of lymphoma is it?

A

young felines (uncommon d/t vax)

T-cell (thymic & multicentric forms)

23
Q

How is lymphoma in horses different from cats & dogs?

A

Multicentric forms typically involve thoracic & abdominal cavities, GI, and cutaneous diseases common

24
Q

What is the most common form of lymphoma in the horse?

Which cell is the neoplastic population?

Where is it commonly located?

A

T-cell rich large B-cell lymphoma

B-cells

multiple SQ nodules****

often need histo to dx

25
Q

Lymphoma in ruminants typically is associated with two forms. What are the two forms?

A

sporadic

BLV associated

26
Q

What are the three types of sporadic lymphoma in ruminants?

A

juvenile (<6mo)

Thymic (6 mo-2 yr)

Cutaneous (1-3 yr) rare

27
Q

Most bovines infected with BLV will develop lymphoma. T/F?

A

FALSE

28
Q

What bloodwork abnormality is suggestive of BLV lymphoma?

A

persistent lymphocytosis

29
Q

What disease is associated with lymphoma in avians?

A

Marek’s disease

30
Q

What is the major difference in the cell population of reactive vs. neoplastic lymphoma cells?

A

reactive: polyclonal, pleomorphism
neoplastic: monoclonal, monomorphic

31
Q

What test is the best dx test to determine if a cell population is lymphoma or not?

A

PARR

32
Q

What dx test is best to determine between B-cell and T-cell lymphoma?

A

flow cytometry

33
Q
A

Cytodiagnostics (9 decks)

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