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UE2 Biocell > Membrane Plasmique > Flashcards

Membrane Plasmique Flashcards

1
Q

Taille membrane plasmique

A

4-6nm

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2
Q

Type de groupement hydrophobes lipides

A

PhosphoL : 1 acude gras sature et un non sature

Sphyngomyeline : 1 sphingoside et 1 acide gras sature A LONGUE CHAINE

Cholesterol : polycyclic

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3
Q

Ou sont synthétises les phospholipides

A

Face cytoplasmique du reticulum (creme est jaune comm eles lipides + de gras ds la creme que la croute du millefeuille)

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4
Q

Type de liaison prot membranaires

A

Trans : hydrophobes dc detergent puissant
Phospholipides : covalentes donc detergent douz ou PLC pour prot ancre gpi
Glyco : ionique

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5
Q

Lieu de synthese prot membranaires

A

Trans : membrane du RE
Lipi : face cytosolique RE phenylees et acylees VS lumiere REpour ancre gpi
Gluco face int ou ext

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6
Q

Qui va sont prot acylees

A

1 acide myristique sur GLY N term

1 acide palmiqtue sur CYS N term

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7
Q

Qui prot phenylees

A

CYS geranyl farnesyk

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8
Q

Eg prot ancre gpi

A

NCAM ou PrPC

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9
Q

Mvt membranaire des lipides

A

Rotation et lateral = rapide

Echange : lent suaf si enzyme

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10
Q

Hb caract

A

Glucophorine : 1 domaine transm et glycosukee sur N ter

Bande 3 : 14trans, N et C cyto

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11
Q

Caract spectrine

A

Prot periph
Double helice
2 chaines

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12
Q

Prot periph de globule rouge

A

= LIEES AU CYTOSQUELETTE

Spectrine ankyrine actine 4.1

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13
Q

Transporteur du gluc props

A

Speci au D glucose
12 domaines transm
7 isoformea
2 conformation

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14
Q

SGLT1

A

Apicale
Gluc sens ANTI gradient
Na sens gradient

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15
Q

Transporteurs m sucres

A

Gluc 5 : fructose apicale

Glut 2 basale glu fruc galac

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16
Q

Transport lysosome et mito

A

H+

Pyruvate

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17
Q

Concentrations NaK

A

3 Na 10 mM à 140mM

2 K 4 mM à 150mM

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18
Q

Certains radeaux permettent rapprochement recepteur m et prot de signalisation

A

Oui

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19
Q

Caract cholesterol

A

Amphi philo

Tete polaire et corps apolaire COMME lipides

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20
Q

Prot m sont transm ?

A

NON

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21
Q

Caract radeaux lipidques

A

Pas riche en cholesterol et sphyngo

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22
Q

Domaines ATPasiques intervient ds gradient de concentraion K et Na

A

Oui pompe active

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23
Q

Pq MO asyn

A

Prot m sont toutes asym

Glycocalix que a ext

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24
Q

Site de l speci pour canaux ioniques ligand dpd

A

Non

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25
Q

Canal ionique est un transporteur passif

A

Non transport par canal PAS transportetur

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26
Q

qd m polarsee, la conformation inactivee est la plus stable

A

non c’est la conformation fermee

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27
Q

deplacement des prot

A

QUE laterale

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28
Q

prot transm inserees ds membrne pdt la transc

A

non car pdt transcirption tu n’as pas de prot

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29
Q

detergent doux pour qui

A

prot asso aux lipides (detergent fprt : prot transm)

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30
Q

fluidite : insturaiton plus import que L des chaines

A

le cours ne dit pas

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31
Q

sphyngomyelines sont des phospholipides

A

oui

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32
Q

sphyngolipides ont cb acides gras

A

1 et sphingoside

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33
Q

trans Na+GLuc, qui est lie en premier

A

easiest = Na+

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34
Q

constitutants MP hepatocytes

A

52L-44P-4G

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35
Q

constitutants MP erythro

A

49-43-8

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36
Q

constitutants MPoligo

A

79-18- 3

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37
Q

constitutants Membranes mito

A

25-75

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38
Q

2 types de phospoholipides

A

sphyngolipides et glerolphospholipides

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39
Q

3 eg sphingoL diff

A

tete: PC –> sphingomyeline

tete : sucre : glycosphingomyeline

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40
Q

qui deter gr sanguins ABO des hematies

A

glucosphingoL

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41
Q

bcp de sphingomyeline ou

A

cornee et tissus nerveux

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42
Q

groupemetn hydrophile du cholestero

A

OH

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43
Q

quelle couche des lpides m energetiquement favo

A

bicouche lipidiquw

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44
Q

compo lipides MP

A

cholesterol - sphyngo - PC

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45
Q

compo lipides interne mito

A

PC&raquo_space;> mais plus de Pe que MP (first ring swimlake loves physics)

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46
Q

compo lipides ext mito

A

PC bcp mais moins m int donc PE max entre les 3 (secnod ring swim lake fit for life)

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47
Q

type de laison prot periph

A

ionique ou HYDROGENES

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48
Q

prot transm : cb de seq de debut et fin de transfert ds translocon

A

plusieurs

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49
Q

insertion des prot transm grace a ouverture ct du translocon

A

LATERALE

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50
Q

struc secondaires ds bcp prot transm

A

helice alpha

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51
Q

interaction possible entre quelles prot

A

periph et transm grce a des liaisons faibles

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52
Q

ct trouver nb de domaines trans m

A

exp d’hydropathie

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53
Q

% des sucres de membrane liees aux prot

A

90%

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54
Q

def glycoprot

A

prot avec des group oligosacchari

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55
Q

def proteoglycane

A

prot + GAG

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56
Q

fonctions des glucides membranaires

A

reconaiisance - ABO - prot mecanique

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57
Q

role MP de erythocte

A

resistance - forme - plasticite

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58
Q

ou se trouve actine ds MP du GR

A

au niveau des cx jonctionnels

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59
Q

elliptocytose 30% des cas mutations sur quelle chaine

A

beta

60
Q

anomalie MP GR 2 impacts possi

A

anemie-hemolyse (ellipto-sphero) ou rigidite membranire (ovalo)

61
Q

1 des roles des translocases (flipases)

A

deplacement des phospholipides de face cyto a luminale du RER

62
Q

fonctions de asymetrie

A

faciliter courbure des membranes

63
Q

fnociton PS dehors

A

reconnue par les macro et

64
Q

PS et coagulation ou

A

chez les plsquettes (diff des GR)

65
Q

quelle face synthese et maturaiton des chaines glucidiques des prot

A

luminale du RER et Golgi

66
Q

3 types de mvt phosphomembranaire

A

rotation - diff laterale - echange transversale

67
Q

qui induit asymetrie des PS et PE

A

flipasse ATP dpd (ds MP)

68
Q

flipase ATP pour tous les phospholipids

A

certinas

69
Q

nom flipasse ATP ind et ou

A

MEMBRANE RER scramblase

70
Q

fonction scramblase

A

repatioj phosphlipides entre le 2 feuilles

71
Q

lien fluidite et chaines saturees

A

chaines insaturees ++=> fluidte ++

72
Q

qui resiste aux detergents

A

radueax lipidiques

73
Q

radeuax lipidiques enrichis en ?

A

choles et sphingp (+ concentration de certaine sprot)

74
Q

ct transduction d’un signal a l’int d’une prot

A

radeaux rapprochent prot de signalisatio te recepteurs membranaires

75
Q

caveoles

A

sphyngomyeline-gangliose-caveoline(feuillet int)-choleterp;

76
Q

MP permet la communication avec qui

A

prot de liaison - reception signuax - plateforme assemblage des cx speci (domaines specialies)

77
Q

prot palmytoisation

A

caevoline

78
Q

prot myristo

A

galpha et SRC

79
Q

prot isopreny

A

ras

80
Q

permeabilite du glycerol

A

moyenne // ethanol uree H2

81
Q

permabilite H2O

A

moenne

82
Q

limite poids mol diffusion siple

A

1kda

83
Q

aquaporeine laissent passer ions

A

NON

84
Q

ou APQ1 et AQP2

A

GR et nephro

85
Q

canal Na+ voltage dpd selon quels gradient

A

electrieu et cimique

86
Q

canaux sont des pores spefiques

A

oui

87
Q

ordre de grandeur changent de conformaiton canal NA+

A

tres rapide : miliseconds

88
Q

ou bcp de canal Na+

A

cell excite : neurones coeur muscle

89
Q

cb de conformation canal Na+

A

3 : polarisee –> fermee - depola : ouvert , inactive (plus stable

90
Q

qui peut degrader acetylcholine

A

cholyne esterase

91
Q

canal ligand acetyl laisse passer TOUS les cations

A

OUI

92
Q

delta t canal acty avt conformaiton ferme et occupe

A

20ms

93
Q

def canal

A
  1. pore
  2. selectif
  3. tran
94
Q

canal : ouverture TJS du a un signal

A

svt

95
Q

canal : monoprot

A

non multiprot gal

96
Q

4 types de signaux pour un canal

A
  1. depol
  2. ligand EC
  3. ligand IC
  4. stimulus meca
97
Q

ligand IC

A

Ca, AMPc. GMPc, ATP

98
Q

ligand EC

A

acetyl, serotonine, GABA, glutamate

99
Q

eg stimulus mecanique signal

A

cell cilees oreilles interne

100
Q

m synap = jonciton sneruomuscu ?

A

oui

101
Q

qui permet secretion acetyl choline

A

ouverture des canaux Ca (eux memes ouverts grace au singal nerveux qui depolarise )

102
Q

ct depolaristion de la membrane apres actylcholine fixee ?

A

entree NA+

103
Q

canal chlore sur quelles cell

A

epi et glandulaires

104
Q

ct sortie du chlore

A

augmentation AMPC int cell

105
Q

mucoviscidose

A

mutaiton de gene CTFR : pas de cal

106
Q

ostruction des canaux pancreites si mucoviscodse

A

oui

107
Q

diarhee hydrique

A

toxine => trop ‘DAMPC

108
Q

diffusion facilite par un canal = diffusion simple

A

non

109
Q

nature des transpo

A

prot TRANsm

110
Q

GLUT : sur TOUTES les cell

A

oui

111
Q

GLUT : struc II des domaines transm

A

helice alpha

112
Q

GLUT quel domaine glycolysee

A

EC

113
Q

GLUT : quel domaine charge

A

LARGE domaine IC charge

114
Q

GLUT : presence de boucles hydrophiles ?

A

oui

115
Q

where glut7

A

m du RER

116
Q

glut a glucose

A

1-4 ds MP

117
Q

GLUT peut faire sortir ?

A

oui

118
Q

pompa Na/K : % ATP cell

A

30%

119
Q

pompa Na/K : maintient des gradients de cb

A

10-30

120
Q

pompa Na/K : pq changet de conformation

A

3Na+ se fixe => phosprylation de la pompe

121
Q

pompa Na/K : qui stimule la depsho de la pompe

A

K

122
Q

transp 2nd actif et cotransporeut sont synonymes

A

pui

123
Q

pq SGLT1 a besoin energie indirect

A

graident de Na+

124
Q

SGLT1 cb de NA et de glucose

A

2Na puis 1 glucose

125
Q

antiprot quelles cell

A

Na/Ca - coeur - Na/H

126
Q

symport ex

A

Na/aa Na/HCO3-

127
Q

lyso : trans H+ passif

A

non actif

128
Q

trans 2e actifs

A

MP :aa

Mito : pyruvate

129
Q

mito : par ou rentre pyruvate et acides gras m EXT

A

porines

130
Q

ct rentre ADP ATP ds mito m EXT

A

canaux

131
Q

mito : comment rentre pyr/acides gras

A

M EXT : porines

m INT : co transport SYMPORT : ACIEDS GRAS/H+

132
Q

qui permet le cotransport mito acides gras et pyru

A

graident de H+

133
Q

new : si inhibituer de farnesyl transferas

A

e empeche la localisation de ras a la membrane

134
Q

new: detergents sous q forme

A

micelle ou de monomeres

135
Q

new: detergents s’asso aux prot pour destabiliser la mb

A

yes

136
Q

new: ct stimulus meca

A

stereoculs ds endolymphe ac bcp de K+ => dplct des cils ==> ouverture des canaux => K+ rentre DANS la cell => depola => inflx nerveux

137
Q

new:qui provoque ouverture canal chlore

A

fixation ATP et AMPc ic

138
Q

new: ou glut 1

A

GR

139
Q

new: ou glut 2

A

rein foie intesin

140
Q

new: ou glut 3

A

neurones

141
Q

new: ou glut 4

A

tissu adipeux , muscle

142
Q

new: ou glut 5

A

intestin

143
Q

glut 2 ds intesin

A

non TUBE digestif

144
Q

ouabaine : inhibiteur de qui

A

pompe NaK

145
Q

ou se fixe ouabaoine

A

fixation sursites EC qui lient le K+

UE2 Biocell (15 decks)

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