MEH Drugs and Treatments

Question 1

Outline the treatment for Hyperalodsteronism.

Answer 1

Spironolactone - mineralocorticoid receptor antagonist

Surgical excision of tumour

Question 2

Name 2 steroid drugs that are used as anti-inflammatory’s and have immune modulator effects.

Answer 2

Prednisolone, dexamethasone

Question 3

What is a precaution that needs to be taken when withdrawing patient from steroid drugs?

Answer 3

Gradual dosage reduction
HPA suppressed due to high steroid level in the bloodstream.
Meaning patient will not be able to synthesise endogenously well enough.

Question 4

What is the treatment for addisonian crisis?

Answer 4

Fluid replacement

IV cortisol

Question 5

What is the mode of action of the drug Pegvisomant?

Answer 5

GH receptor antagonist

Question 6

What drugs are given in treatment of type II diabetes and what is their mode of action?

Answer 6

Sulphonylureas - Decrease insulin resistance and increase insulin production.

Metformin - decrease gluconeogenesis

Question 7

What is the treatment for Hasimoto’s disease?

Answer 7

Oral T4

Question 8

What is used to treat thyrotoxicosis?

How does this drug work?

What is it converted to in the body?

What is a sideffect?

Answer 8

Carbimazole

Prevent formation of thyroid hormone by preventing thyroid peroxide coupling and iodination.

Methimazole

Neutropenia