Hyperlipoproteinaemias Flashcards
What is increased in Type I hyperliproteinaemias?
Why is it increased?
High chylomicrons in fasting plasma
Defective LPL
What is increased in type IIa hyperlipoproteinaemia?
Why is it increased?
Increased LDLs
Defective LDL receptor
What is increased in type III hyperlipoproteinaemias?
Why is it increased?
IDL and chylomicron remnants
Defective apoE
In hyperlipoproteinaemia treatment, what are some dietary changed that should be undertaken?
Less cholesterol and saturated fats
More fibre
In hyperlipoproteinaemia treatment, what are some lifestyle changes that should be undertaken?
Stop smoking - decreased CVD
More exercise
Name a statin.
Atorvastatin
Name a bile salt sequestrant and state their action.
Colestipol
Bind bile salts in GI tract meaning more need to be synthesised by the liver thus using up more cholesterol for their synthesis.
