Control Of Apetite

Question 1

What are the NTs of the primary stimulatory nucleus of the arcuate nucleus?

Answer 1

AgRP

NPY

Question 2

What are the NTs of the primary inhibitory neurone of the arcuate nucleus and what receptors do they act on?

Answer 2

a-MSH (derived from POMC)

Act on MC4 receptors

Question 3

Name 4 hormones that promote satiety and where are they made.

Answer 3

Leptin - adipocytes
PYY - ileum
Amylin - Pancreas
Insulin - Pancreas

Question 4

What is the name of the amylin analogue used in treatment of type II diabetes?

Answer 4

Pramlintide

Question 5

Describe the how receptor binding to tyrosine kinase receptors results in a response. (4marks)

Answer 5

Dimerisation of the beta sub units
Autophosphorylation of tyrosine
Adapter protein recruitment and signalling complec formation
Phosphorylation of target proteins