Iron Deficiency Anaemia Flashcards
1
Q
What is seen in the FBC results for iron deficiency anaemia?
A
Low Hb Low MCV Low MCHC Elevated platelets Normal/elevated WBC Low serum iron Low %transferrin sat High TIBC Low CHr
2
Q
What will be seen in the peripheral blood smear of iron deficiency anaemia?
A
Microcytic and hypochromic redblood cells
Pencil and target cells
Anisopoikilocytosis
3
Q
What is the test recommended for functional iron deficiency?
When is it not useful and why?
A
CHr
During inflammatory responses and in thalassaemic patients because it remains low in these.
4
Q
Name 2 reasons why iron excess is bad
A
Haemosiderin deposition
Promotion of free radical formation via the Fenton reaction
5
Q
What does accumulation of haemosiderin in organs lead to?
A
ACHILD
Arthropathy Cardiomyopathy Hypogonadism Increased skin pigmentation Liver cirrhosis Diabetes M
6
Q
How is hereditary haemochromatosis inherited and what mutation is the gene on and what chromosome is involved?
A
Autosomal recessive HFE Chr 6
