Medications Flashcards
Bleomycin (Blenozane)
Classification: antitumor antibiotic
Indication: HD, HNL, sq cell HN, melanoma, sq of skin, cervix, vulva, testicular
Route: IV, SC, IM
Side Effects: pulmonary toxicity, renal toxicity
Doxorubicin (Adriamycin or Rubex)
Classification: antitumor antibiotic, anthracyclines
Indication: breast, liver, lung, ovarian, prostate; NHL, HD, MM, ALL, AML; sq HN
Route: IV
Side Effects: myelosuppression, N/V, mucositis, diarrhea, anorexia
Doxorubicin liposomal (Doxil)
Classification: antitumor antibiotic, anthracyclines
Indication: AIDS-related Kaposi’s Sarcoma, ovarian, MM, sarcoma, Heptocellular CA
Route: IV
Side Effects: myelosuppression, N/V, mucositis, diarrhea
Etoposide (VePesid or VP-16)
Classification: Epipodophyllotoxins
Indication: small & nonsmall lung CA, HD, NHL, gastric CA, germ cell tumors (testicular)
Route: IV
Side Effects: myelosuppression, N/V, mucositis, diarrhea, metallic taste
Vincristine (Oncovin)
Classification: Vinca alkaloids
Indication: ALL, AML, CML, D, NHL, MM, sm cell lung CA, rhabdomyosarcoma, neuroblastoma, Ewing’s sarcoma, Wilms’ tumor, brain & thyroid CA
Route: IV
Side Effects: myelosuppression, sensory neuropathy, constipation, jaw pain
Interactions: decrease drug activity - St. John’s Wort, phenobarbital dexamethasone; increase drug activity - grapefruit, ketoconazole, erythromycin
*Omega-3’s may enhance clinical benefit of Vincristine
Vinblastine (Velban)
Classification: Vinca Alkaloids
Indication: Breast, testicular, HD, sq cell NH, sarcoma
Route: IV
Side Effects: myelosuppression, mucositis, stomatitis, constipation, jaw pain, HTN
Interactions: decrease drug activity - St. John’s Wort, phenobarbital dexamethasone; increase drug activity - grapefruit, ketoconazole, erythromycin
Vinorelbine (Navelbine)
Classification: Vinca alkaloids
Indication: Breast, ovarian, non-sm cell lung CA
Route: IV
Side Effects: Myelosuppression, N/V, stomatitis, constipation, anorexia, elevated liver function tests
Rituximab (Rituxan)
Classification: monoclonal antibody CD20
Indication: B-cell NHL, CLL
Route: IV
Side Effects: infusion reaction, myelosuppression, tumor lysis syndrome, skin reactions, mild N/V
Pertuzumab (Perjeta)
Classification: monoclonal antibody Her2/neu
Indication: metastatic breast CA
Route: IV
Side Effects: infusion reaction, myelosuppression, asthenia, infections, mild N/V, cough, dyspnea, sinusitus
Trastuzumab (Herceptin)
Classification: monoclonal antibody Her2/neu
Indication: metastatic breast CA, metastatic gastric CA
Route: IV
Side Effects: infusion reaction, myelosuppression (rare), cardio-toxicity, N/V, mild D, pulmonary toxicity
Panitumumab (Vectibix)
Classification: monoclonal antibody EGFR
Indication: colorectal CA
Route: IV
Side Effects: infusion reaction, acneiform skin rash, pruritis, pulmonary toxicity, hypomagnesemia, Diarrhea, malaise
Interactions/concerns: hypomagnesemia – monitor Mg closely, particularly with elderly or pts with low baseline Mg
Cetuximab (Erbitux)
Classification: monoclonal antibody EGFR
Indication: colorectal CA, NH
Route: IV
Side Effects: infusion reaction, acneiform skin rash, pruritis, pulmonary toxicity, hypomagnesemia, Diarrhea, malaise, N/V, anorexia
Interactions/concerns: hypomagnesemia – monitor Mg closely, particularly with elderly or pts with low baseline Mg and received Oxalipatin (Eloxatin)
Megesterol acetate (Megace)
Classification: progesterone
Indication: breast, endrometrial, renal cell. Also appetite stimulant in CA and AIDS
Route: PO
Side Effects: weight gain (fluid retention), thromboembolic events, N/V, menstral bleeding, hot flashes, sweating, mood change, hyperglycemia
Carboplatin (Paraplatin)
Classification: alkylating agent
Indication: bladder, endometrial, germ cell, HN, lung, ovarian
Route: IV
Side Effects: myelosuppression, N/V!, renal toxicity, hypersensitivity reaction, alopecia, peripheral neuropathy
Cisplatin (Platinol or CDDP)
Classification: alkylating agent
Indication: bladder, cervical, esophageal, HN, lung, NHL, ovarian, prostate, testicular
Route: IV
Side Effects: Acute and delayed N/V, metallic state, myelosuppression, peripheral neuropathy, SIADH, renal toxicity, hypomagnesmia, ototoxicity, infusion reaction
Rigorous hydration is needed to prevent nephrotoxicity (PO and IVF). Monitor renal function/lytes. At risk include elderly, low Mg pts, impaired renal function at baseline
Interactions: Omega-3’s may enhance clinical benefits of Cisplatin; Curcumin - may sensitize cisplatin-resistant cells to cisplatin, improving efficacy. May reduce cisplatin-induced neurotoxicity. Safe to add into diet.
Cyclophosphamide (Cytoxan, CTX)
Classification: alkylating agent
Indication: breast, ovarian, MM, NHL, HD, CLL, Mycosis fungoides, neuroblastoma, sarcoma, Wilm’s tumors
Route: PO, IP, IV. When taken oral - take early in the day with vigorous hydration (3L) throughout the day.
Side Effects: Myelosuppression, N/V, bladder and cardiac toxicity, SIAD, Alopecia
Interaction: may increase effects of anti-coagulation so anticoag meds may need to be reduced