Med part 2 Flashcards
What are the CYP3A4 inducers?
St John’s Wort
Phenobarbital
What are the CYP3A4 inhibitors?
Grapefruit juice
ketoconazole
erythromycin
What medications interact with CYP3A4 pathways?
Axitnib - Inlyta Dasatinib - Sprycel Erlotinib - Tarceva Everolimus - Afinitor Imatinib - Gleevac Sunitinib - Sutent Tamoxifen - Nolvadex Vinblastine - Velban Vincristine - Oncovin
What drugs requires a stool softener/laxatives to avoid severe constipation as a side effect?
Vincristine - Oncovin
Vinblastine - Velban
What drugs alter glucose metabolism?
Temirolimus - Torrisel (hyper)
Streptozocin - Zanosar (hypo)
What drug should you avoid taking antacids within 2 hours of?
Tamoxifen - Nolvadex
What drug interacts with fat content in meals?
Regorafenib - Stivarga
What drug interacts with tyramine (requiring avoiding taking while on drug and for 2 weeks after)?
Procarbazine Hydrochloride - Matulane
What drug requires folic acid and Vit B12 supplementation?
Pemetrexed - Alimta
What drug has strong sensitivity to cold?
Oxaliplatin - Eloxatin
What 3 drugs have a side effect of hand-foot syndrome and should be supplemented with B6?
Oxaliplatin - Eloxatin
Fluorouracil - 5-FU or Adrucil
Capecitabine - Xeloda
What drug is recommended to avoid folic acid with?
Methotrexate Folex - Rheumatrex
What drug has an increased risk of mucositis during infusion? What’s the recommendation to help avoid that?
Fluorouracil - 5-FU or Adrucil
melt ice chips in mouth 10-15 minutes pre and post bolus infusion
What drugs contain lactose?
Nilotinib - Tasigna
Deferasiox - Exjade
What drugs requires vigorous oral hydration (3 liters)?
Cyclophosphamide - Cytoxan
Cisplatin - Platinol
