Medications Flashcards
What does warfarin target?
Vitamin k dependent clotting factors 2, 7, 9, 10, protein s and protein c
What is the initial effect of warfarin?
Hypercoagulation
What does desmopressin do?
Releases factor VII bound to endothelial cells resulting in a temporary boost to factor VII levels
Why is desmopressin only effective every few weeks?
Factor VII needs to build up in the endothelial wall
How does transaeximic acid work?
Inhibits fibrinolysis
Decreases bleeding by stopping clot breakdown
What is the maximum dose of paracetamol?
0.5-1g every 4-6 weeks
Max 4g per day
What is the maximum dose of ibuprofen?
400mg tablet 4x per day
Max 2.4g per day
What is the maximum dose of aspirin?
300mg tablet (x2) 4x a day
Max 4g per day
What is the maximum dose of dihydrocodeine?
30mg every 4-6 hours
What is the maximum dose of carbamazepine?
200mg 3-4 times a day
Up to 1.6g
What is the maximum dose of diclofenac?
15ml rinse 2-3x day for 7 days
What medications can be used to treat NUG/NUP?
Metronidazole
6% H2O2
0.2% chlorhexidine mouthwash
When is chlorhexidine used?
Post surgery
Disabled patients
Immunocompromised
RCT irritant
What are the side effects of chlorhexidine?
Decreased GI absorption
Staining
Taste disturbance
What are the side effects of chemotherapy?
Hair loss
Fatigue
Nausea
Weakness
What are the side effects of radiotherapy?
ORN
Mucositis
Burns
Radiation caries
What is apixaban?
Direct Oral Anticoagulant
What is apixaban used for?
Deep Vein Thrombosis
Pulmonary Embolism
Stroke
Non-vascular atrial fibrillation
How long does warfarin take to work?
48-72 hours
What its the mode of action of dabigatran?
Reversible inhibitor of free thrombin, fibrin bound thrombin and thrombin-induced platelet aggregation
What is the mode of action of apixaban, edoxaban and rivaroxiban?
Factor Xa inhibitors
Prevent thrombin generation and thrombus development
What is simvastatin?
HMG CoA reductase inhibitors used to treat hypercholesteroemia
What is furosemide?
Loop diuretic
What is furosemide used for?
Controls hypertension
What is a risk with furosemide?
Risk of exacerbating diabetes
What is carvedilol?
Beta blocker
What is carvedilol used for?
Hypertension management
What is the effect of metformin?
Anti-hyperglycaemic effect
What is a side effect of metformin?
Can reduce vitamin B12 levels: leads to vitamin B12 deficiency anaemia
What is the mode of action of dapagliflozin?
Reversibly inhibits sodium-glucose co-transporter 2 (SGLT2) in the renal proximal convoluted tubule to reduce glucose reabsorption and increase urinary excretion
What is the mode of action of sulfonulurea?
Augments insulin secretion
Only effective when there is residual pancreatic beta-cell activity