Med Chem

Question 1

Where is M1 present?

Answer 1

Gastric cells

Question 2

Where is M2 present?

Answer 2

Heart

Question 3

Where is M3 present?

Answer 3

Eyes, lungs, GIT, urinary bladder, glands

Question 4

Which is the starting material for the biosynthesis of Acetylcholine?

Answer 4

Serine

Question 5

What is the process of biosynthesis of Acetylcholine?

Answer 5

Serine (decarboxylation) - Ethanol amine (SAM, NMT) - Choline + Acetyl choline (CAT) - Acetylcholine

Question 6

What does Hemicolinium do?

Answer 6

Inhibits the uptake of choline

Question 7

What does Vesamicol do?

Answer 7

Inhibits the storage of Ach

Question 8

What does Botulinium toxin do?

Answer 8

Inhibits the release of Ach in the synapse

Question 9

What are the uses of Pilocarpine?

Answer 9

1. Glaucoma
2. Can be used for dry mouth
3. Sjogrem’s syndrome (dry mouth, throat, esophagus)

Question 10

What is the use of Bethanicol?

Answer 10

Atonic bladder

Question 11

Use of Methacholine

Answer 11

Tachycardia and Tachyarrythmia

Question 12

Use of Physostigmine

Answer 12

1. Can be given for Atropine poisoning
2. Glaucoma

Question 13

Which is the drug that is given for Methanol poisoning

Answer 13

Fomepizole

Question 14

What bond do Organophosphates make with the Ach enzyme?

Answer 14

Covalent bond

Question 15

Give examples for natural anti-cholinergic drugs

Answer 15

Atropine, Hyoscine (scopolamine)

Question 16

What can Ipratropium bromide be used for?

Answer 16

COPD, asthma, PRE-ANESTHETIC med

Question 17

Uses of Cyclopentolate

Answer 17

1. Midriatic agent
2. Cyclopegic agent
3. Treatment of Uveitis

Question 18

Uses of Glycopyrrolate

Answer 18

Pre-anesthetic medication

Question 19

Uses of Tropicamide

Answer 19

1. Midriatic agent
2. Cyclopegic agent
3. For the fundoscopic examination of eye

Question 20

Uses of Isopropamide

Answer 20

For peptic ulcers

Question 21

D.O.C for Parkinson’s

Answer 21

Benzhexol, Bipyriden, Benztropin

Question 22

Name some tocolytics

Answer 22

Salbutamol, Terbutaline, Ritodrine

Question 23

Name some Nasal decongestants

Answer 23

Xylomethazoline, Oxymethazoline, Naphazoline

Question 24

Anorectants

Answer 24

Sibutramine, Fenfluramine

Question 25

What are the uses of Adrenaline?

Answer 25

1. Local anesthetic 2. Pre-anesthetic 3. Cardiac shock (1:10,000 or 0.01%)

Question 26

What is the D.O.C of anaphylactic shock?

Answer 26

Adrenaline (sub-cutaneous, intra-muscular)

Question 27

Which form of Nor-adrenaline is most potent?

Answer 27

Levo form

Question 28

What are the conditions in which Dopamine is used?

Answer 28

Olego urea shock

Question 29

Which drug is used for Hypertension in pregnancy?

Answer 29

Methyl DOPA

Question 30

Salbutamol is... A. Levo B. Dextro C. Racemic

Answer 30

Racemic

Question 31

What is the use of R(-)Salbutamol?

Answer 31

Pharmacological activity

Question 32

What is the use of S(+)Salbutamol?

Answer 32

Prevents elimination

Question 33

Which is the prodrug of Colterol?

Answer 33

Bitolterol

Question 34

Name some CNS stimulants

Answer 34

Amphetamine, Hydroxyamphetamine, Methamphetamine

Question 35

Which drug can be given for ADHD?

Answer 35

Amphetamine

Question 36

Name 2 mixed acting sympathomimetic drug

Answer 36

Ephedrine, Metarminol

Question 37

What are the uses of Phenoxybenzamine?

Answer 37

Pheochromacytoma

Question 38

What are the uses of Tolazoline?

Answer 38

1. Cheese reaction 2. Chlonidine withdrawal symptoms

Question 39

Which is the fastest acting General Anesthetic?

Answer 39

Xenone or Desflourane

Question 40

Slowest acting general anesthetic

Answer 40

N2O

Question 41

What is Halothane preserved in?

Answer 41

Thymol

Question 42

Isoflourane is the isomer of...

Answer 42

Enflourane

Question 43

Which is the most potent GA?

Answer 43

Methoxyflourane

Question 44

Which is the DOC for anesthesia for children?

Answer 44

Ketamine

Question 45

What are the ADRs of Ketamine?

Answer 45

1. Cannot be used for brain surgery (because of increased intra-cranial pressure) 2. Not preffered for glaucoma due to increased intra ocular pr

Question 46

Why is Thiopentone Na+ short and fast acting?

Answer 46

Due to rapid redistribution in the body

Question 47

What is the IUPAC name of Codeine?

Answer 47

3-methyl morphine

Question 48

What is the IUPAC name of Heroin?

Answer 48

3,6 - diacetyl morphine It is also called brown sugar

Question 49

Name 2 opioid drugs that are used to induce diarrhoea in non-infectious cases?

Answer 49

Diphenoxalate and Loperamide

Question 50

Which is the drug used for de-addiction of Opiods?

Answer 50

Methadone

Question 51

DOC for Morphine poisoning

Answer 51

Naloxone

Question 52

Which isomer of Dextropropoxyphen has anti-tussive activity?

Answer 52

Dextro isomer

Question 53

Name some pure antagonists?

Answer 53

Naloxone (IV) and Naltrexone (oral)

Question 54

What is the basic nucleus of all steroids?

Answer 54

Cyclo pentane perhydro phenanthrene ring (Stearane ring)

Question 55

What is meant by alpha configuration?

Answer 55

The substitutions are present below the plane of the nucleus

Question 56

What is beta configuration?

Answer 56

The substitutions are present above the plane of the nucleus

Question 57

Steroids, on dehydrogenation with Se at 360°C yield...

Answer 57

Diel's hydrocarbon

Question 58

Steroids, upon dehydrogenation with Se at 420°C yield...

Answer 58

Chrysene and Picene

Question 59

Which is the parent carbon of Testosterone?

Answer 59

Androstane

Question 60

How many carbon atoms does Testosterone have?

Answer 60

19 C

Question 61

Parent carbon of Estrogen

Answer 61

Estrane

Question 62

How many carbon atoms does Estrogen have?

Answer 62

18 C

Question 63

Parent carbon of progesterone and adenocorticol hormones

Answer 63

Pregnane

Question 64

How many carbon atoms does Pregnane have?

Answer 64

21 C

Question 65

Which salt form of Cortisone is most in use?

Answer 65

Cortisone Acetate

Question 66

IUPAC name of Estrone

Answer 66

3-hydroxy estra-1,3,5-(10)-trien-17-one

Question 67

Synonym of Hydrocortisone

Answer 67

Cortisol

Question 68

Structure of Dexamethasone

Answer 68

16 alpha isomer of Betamethasone

Question 69

Name some natural Estrogens

Answer 69

Estradiol, Estrone, Estriol

Question 70

Semi-synthetic estrogens

Answer 70

Ethinyl estradiol, Mestranol

Question 71

Synthetic estrogens

Answer 71

Stilbesterol, Dienosterol

Question 72

Capreomycin is a mixture of what polypeptides?

Answer 72

Capreomycin is a mixture of IA, IB, IIA and IIB Out of this, Capreomycin IA and IB ARE CLINICALLY USRD

Question 73

What is Rifampin derived from?

Answer 73

It is a semi-synthetic drug derived from Streptomyces mediterrani

Question 74

Which isomer of Ethambutol is more potent?

Answer 74

Dextro isomer is more potent than the levo isomer bu 200 or 500 times

Question 75

Is Rifampin a broad or narrow spectrum antibiotic?

Answer 75

Broad spectrum

Question 76

What drug is the Primary choice for treating tuberculosis?

Answer 76

Isoniazid

Question 77

What drug is first line for treating short term tuberculosis?

Answer 77

Pyrizinamide because of its LOW SHORT TERM TOXICITY

Question 78

Which drug is effective against tubercle bacilli resistant to Isoniazid and Streptomycin?

Answer 78

Ethambutol

Question 79

What are quinolones generally used for?

Answer 79

Ocular infections, skin infections and mostly for UTIs

Question 80

Which quinolone drug is used for prophylaxis infections after trans-urethral surgery?

Answer 80

Lomefloxacin (also called Maxaquine)

Question 81

What is the general MOA of Quinolones?

Answer 81

Interrupting the synthesis of DNA by inhibiting DNA gyrase and topoisomerase IV