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Things I Keep Forgetting > Med Chem > Flashcards

Med Chem Flashcards

1
Q

Where is M1 present?

A

Gastric cells

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2
Q

Where is M2 present?

A

Heart

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3
Q

Where is M3 present?

A

Eyes, lungs, GIT, urinary bladder, glands

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4
Q

Which is the starting material for the biosynthesis of Acetylcholine?

A

Serine

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5
Q

What is the process of biosynthesis of Acetylcholine?

A

Serine (decarboxylation) - Ethanol amine (SAM, NMT) - Choline + Acetyl choline (CAT) - Acetylcholine

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6
Q

What does Hemicolinium do?

A

Inhibits the uptake of choline

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7
Q

What does Vesamicol do?

A

Inhibits the storage of Ach

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8
Q

What does Botulinium toxin do?

A

Inhibits the release of Ach in the synapse

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9
Q

What are the uses of Pilocarpine?

A
  1. Glaucoma
  2. Can be used for dry mouth
  3. Sjogrem’s syndrome (dry mouth, throat, esophagus)
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10
Q

What is the use of Bethanicol?

A

Atonic bladder

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11
Q

Use of Methacholine

A

Tachycardia and Tachyarrythmia

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12
Q

Use of Physostigmine

A
  1. Can be given for Atropine poisoning
  2. Glaucoma
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13
Q

Which is the drug that is given for Methanol poisoning

A

Fomepizole

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14
Q

What bond do Organophosphates make with the Ach enzyme?

A

Covalent bond

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15
Q

Give examples for natural anti-cholinergic drugs

A

Atropine, Hyoscine (scopolamine)

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16
Q

What can Ipratropium bromide be used for?

A

COPD, asthma, PRE-ANESTHETIC med

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17
Q
A
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18
Q

Uses of Cyclopentolate

A
  1. Midriatic agent
  2. Cyclopegic agent
  3. Treatment of Uveitis
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19
Q

Uses of Glycopyrrolate

A

Pre-anesthetic medication

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20
Q

Uses of Tropicamide

A
  1. Midriatic agent
  2. Cyclopegic agent
  3. For the fundoscopic examination of eye
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21
Q

Uses of Isopropamide

A

For peptic ulcers

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22
Q

D.O.C for Parkinson’s

A

Benzhexol, Bipyriden, Benztropin

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23
Q

Name some tocolytics

A

Salbutamol, Terbutaline, Ritodrine

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24
Q

Name some Nasal decongestants

A

Xylomethazoline, Oxymethazoline, Naphazoline

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25
Q

Anorectants

A

Sibutramine, Fenfluramine

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26
Q

What are the uses of Adrenaline?

A
  1. Local anesthetic
  2. Pre-anesthetic
  3. Cardiac shock (1:10,000 or 0.01%)
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27
Q

What is the D.O.C of anaphylactic shock?

A

Adrenaline (sub-cutaneous, intra-muscular)

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28
Q

Which form of Nor-adrenaline is most potent?

A

Levo form

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29
Q

What are the conditions in which Dopamine is used?

A

Olego urea shock

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30
Q

Which drug is used for Hypertension in pregnancy?

A

Methyl DOPA

31
Q

Salbutamol is…
A. Levo
B. Dextro
C. Racemic

32
Q

What is the use of R(-)Salbutamol?

A

Pharmacological activity

33
Q

What is the use of S(+)Salbutamol?

A

Prevents elimination

34
Q

Which is the prodrug of Colterol?

A

Bitolterol

35
Q

Name some CNS stimulants

A

Amphetamine, Hydroxyamphetamine, Methamphetamine

36
Q

Which drug can be given for ADHD?

A

Amphetamine

37
Q

Name 2 mixed acting sympathomimetic drug

A

Ephedrine, Metarminol

38
Q

What are the uses of Phenoxybenzamine?

A

Pheochromacytoma

39
Q

What are the uses of Tolazoline?

A
  1. Cheese reaction
  2. Chlonidine withdrawal symptoms
40
Q

Which is the fastest acting General Anesthetic?

A

Xenone or Desflourane

41
Q

Slowest acting general anesthetic

42
Q

What is Halothane preserved in?

43
Q

Isoflourane is the isomer of…

A

Enflourane

44
Q

Which is the most potent GA?

A

Methoxyflourane

45
Q

Which is the DOC for anesthesia for children?

46
Q

What are the ADRs of Ketamine?

A
  1. Cannot be used for brain surgery (because of increased intra-cranial pressure)
  2. Not preffered for glaucoma due to increased intra ocular pr
47
Q

Why is Thiopentone Na+ short and fast acting?

A

Due to rapid redistribution in the body

48
Q

What is the IUPAC name of Codeine?

A

3-methyl morphine

49
Q

What is the IUPAC name of Heroin?

A

3,6 - diacetyl morphine

It is also called brown sugar

50
Q

Name 2 opioid drugs that are used to induce diarrhoea in non-infectious cases?

A

Diphenoxalate and Loperamide

51
Q

Which is the drug used for de-addiction of Opiods?

52
Q

DOC for Morphine poisoning

53
Q

Which isomer of Dextropropoxyphen has anti-tussive activity?

A

Dextro isomer

54
Q

Name some pure antagonists?

A

Naloxone (IV) and Naltrexone (oral)

55
Q

What is the basic nucleus of all steroids?

A

Cyclo pentane perhydro phenanthrene ring (Stearane ring)

56
Q

What is meant by alpha configuration?

A

The substitutions are present below the plane of the nucleus

57
Q

What is beta configuration?

A

The substitutions are present above the plane of the nucleus

58
Q

Steroids, on dehydrogenation with Se at 360°C yield…

A

Diel’s hydrocarbon

59
Q

Steroids, upon dehydrogenation with Se at 420°C yield…

A

Chrysene and Picene

61
Q

Which is the parent carbon of Testosterone?

A

Androstane

62
Q

How many carbon atoms does Testosterone have?

63
Q

Parent carbon of Estrogen

64
Q

How many carbon atoms does Estrogen have?

65
Q

Parent carbon of progesterone and adenocorticol hormones

66
Q

How many carbon atoms does Pregnane have?

67
Q

Which salt form of Cortisone is most in use?

A

Cortisone Acetate

68
Q

IUPAC name of Estrone

A

3-hydroxy estra-1,3,5-(10)-trien-17-one

69
Q

Synonym of Hydrocortisone

70
Q

Structure of Dexamethasone

A

16 alpha isomer of Betamethasone

71
Q

Name some natural Estrogens

A

Estradiol, Estrone, Estriol

72
Q

Semi-synthetic estrogens

A

Ethinyl estradiol, Mestranol

73
Q

Synthetic estrogens

A

Stilbesterol, Dienosterol

Things I Keep Forgetting (11 decks)

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