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Things I Keep Forgetting > MCQs From Med Chem > Flashcards

MCQs From Med Chem Flashcards

1
Q

What is Phenoxybenzamine derived from?

A

Beta halo alkyl amine

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2
Q

What is Tamsulosin derived from?

A

Aryl sulphonamide

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3
Q

How does Phenoxybenzamine act?

A

It acts:
1. Directly on alpha receptor
2. Irreversibly blocks alpha receptor
3. Forms Ethylene iminium ion

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4
Q

What is Chlonidine used for?

A

Migraine, glaucoma, opioid withdrawal symptoms

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5
Q

Which selective beta-2 agonist is not metabolised by COMT?

A

Pirbuterol

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6
Q

What is Betaxolol used for?

A

It is a long acting beta blocker that is used for Glaucoma

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7
Q

Name the heterocyclic rings present in Timolol

A

1,2,5 - Thiadiazole and Morpholine

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8
Q

Which is the amino acid that Muscarinic receptor contains as a residue for parasympathetic activity?

A

Aspartic acid

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9
Q

Which is the drug used for the diagnosis of Myesthenia Gravis?

A

Edrophonium

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10
Q

Name a hydrophilic organophosphate drug

A

Ecothiophate

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11
Q

Name a selective novel M3 antagonist

A

Darifenacin

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12
Q

What is Oxotremorin used for?

A

Alzheimer’s disease and Parkinson’s disease

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13
Q

What is the property of Disulfiram?

A

It inhibits DOPA hydroxylase in Nor-adrenaline synthesis

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14
Q

What isomer is Pseudo-ephedrine?

A

Threo isomer

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15
Q

What is the IUPAC name of Testosterone?

A

17 beta hydroxyl androst-4-ene-3-one

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16
Q

What is the starting material of Diethyl stilbestrol?

A

Anesaldehyde

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17
Q

Name 2 drugs having estrogen property

A

Gossypol and Genistein

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18
Q

Name 3 drugs having anti-estrogenic activity

A

BOMT, Coumesterol, Flutamide

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19
Q

Name 2 progesterone antagonizing drugs

A

Gossypol and Mifeprestone

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20
Q

Oxime is used as an antidote for what poisoning?

A

Carbamate and Organophosphate poisoning (except Neostigmine)

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21
Q

Which is the reagent used for the conversion of Hydrocortisone to Cortisone?

A

m - CPBA (meta chloro peroxy benzoic acid)

22
Q

From what compound is Cimetidine synthesized?

23
Q

Addn of 3C to Pregnolone gives…

A

Bufadienolide

24
Q

How many OH groups and double bonds does Cholesterol contain?

A

1 OH group and 1 double bond

25
Q

Which anti-biotic causes Terfenadine cardiotoxicity?

A

Erythromycin

26
Q

Name a second generation anti-histamine that is also a metabolite of Hydroxyzine

27
Q

What is the basic ring present in Nizatidine?

28
Q

Absorption of what drug is inhibited by Cimetidine?

A

Ketoconazole

29
Q

Which drug is given for Athlet’s foot?

A

Clioquinol

30
Q

What is Athlet’s foot?

A

It is a condition involving fungal infection of the skin in the foot

Also called Tinea pedis

31
Q

Which is the basic ring present in Cicloprox?

A

2-pyridone

32
Q

What is the MOA of Chloroquine?

A
  • of DNA and RNA polymerase
33
Q

What stereoisomer of Quinine is Quinidine?

A

(+) stereoisomer

34
Q

Which AA is the starting material for the synthesis of Hemoglobin?

A

Glycine

Starting material is (Glycine + succinyl CoA)

35
Q

Which is the rate limiting enzyme for the synthesis of Haemoglobin?

A

Amino levulenic acid synthase (ALA synthase)

36
Q

Where does the process of Hemoglobin synthesis occur?

A

Half occurs in MITOCHONDRIA and half in CYTOPLASM

37
Q

What are 2 types of drugs used for the treatment of HIV?

A

Reverse transcriptase inhibitors (they can be Competitive or Non-competitive)

38
Q

What are the 2 types of Competitive RTIs?

A

They are also called NRTI

N can stand for Nuceoside reverse transcriptase inhibitor
OR
Nucleotide reverse transcriptase inhibitor

39
Q

Examples for Nucleoside Reverse Transcriptase inhibitor

A

Zidovudine
Lamivudine
Stavudine
Didanosine
Abacavir
Zalcitibine

40
Q

Examples for Nucleotide Reverse Transcriptase Inhibitor

41
Q

Examples for Non-Nucleotide Reverse transcriptase inhibitor

A

They fall under Non-competitive RTIs

*1st generation drugs:
Efavirenz
Nevirapine
Delaviridine (END)

*2nd generation drugs
Rilpirine
Etravirine
Doravirine (RED)

42
Q

What happens to the fraction of the drug that isn’t bioavailable in the body?

A

It could’ve been unabsorbed or it could’ve gone First Pass Metabolism or pre-systemic metabolism

43
Q

What are the 3 drugs present in the Universal Antidote?

A

Activated Charcoal : Tannic acid : ZnO/MgO

In the ratio 2:1:1

44
Q

What is the role of activated charcoal present in the Universal antidote?

A

Adsorbs the poison on the surface
It is given in the qnty - 1g/kg if body wt.

*It is an example for physical or mechanical antidote

45
Q

What is the role of Tannic acid present in the Universal Antidote?

A

It precipitates alkaloids

46
Q

What is the role of ZnO/MgO?

A

It either neutralizes the acid or brings about the oxidization of alkaloidal compounds

47
Q

Causes for Anemia

A
  1. Pb poisoning
  2. Cu, Vit B9, B12 deficiency
  3. Sideroblastic anemia
  4. Thalassemia
  5. Anemia of chronic diseases
48
Q

Ideal Hematocrit levels

A

For men - less than 0.41
For women - less than 0.38

49
Q

What is Zero order kinetics?

A

Content AMOUNT of drugs would be removed

50
Q

What is First Order kinetics?

A

Constant FRACTION of drugs would be removed

Things I Keep Forgetting (11 decks)

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