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Pharmacology 1 > MCQ > Flashcards

MCQ Flashcards

1
Q

The following can be a drug target

a) Receptor
b) enzyme
c) transportor
d) all choices of drug targets

A

a

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2
Q

BDZ bind to which molecule to exert their CNS effects?

a) GABA A receptor
b) Cl- channel
c) GABAa receptor
d) Na channel

A

Gaba A receptor

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3
Q

What is the effect of binding of BDZs on GABA a receptor?

a) increases Cl- ion efflux
b) increase binding of BDZs
c) increasing the affinity of the receptor to GABA
d) increases NA ion conduction

A

increases affinity of receptor for GABA

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4
Q

whta is the effect of BDZs on neurons excitability?

a) increases
b) no effect
c) decreases

A

decreases

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5
Q

How do BDZs potentiate the effects of GABA A?

a) increased CA ion conductance
b) increased K ion conductance
c) increased Cl- ion ocnductance
d) increased Na ion conductance

A

increased Cl ion conductance

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6
Q

BDZs can have a long duration of action due to..

a) the presence of active metabolites
b) the persistence of inactive metabolites
c) the immediate reception in glutamate conjugates
d) their short half lives

A

the presence of active metabolites

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7
Q

What is the appropriate drug to give in a patient with BDZ overdose?

a) IV sugimmedrix
b) IV iotropine
c) IV anticholinesterase
d) IV fumeril

A

IV fumeril

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8
Q

Which fibres detect nociception?

a) AB
b) Bo
c) C
d) D

A

C

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9
Q

What is the function of the substantial gelatinosa?

a) inhibit C fibres
b) inhibit opioid receptors
c) inhibit the secondary neutrons linked to the thalamus
d) inhibit descending inhibiting pathways

A

inhibit the secondary neutrons linked to the thalamus

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10
Q

which is a natural opiate drug?

a) morphine
b) buprenephrine
c) pethidine
d) methadone

A

morphine

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11
Q

what is the mechanism action of opioids

a) decrease adenyl cyclase activity
b) increase in K ion efflux
c) increase CAMP levels
d) increase in Ca ion influx

A

increases in K ion efflux

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12
Q

which opioid receptor produces dysphoria?

a) u
b) o
c) K
d) ORL-1

A

K

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13
Q

what is the commonest cause of death in opiate poisoning?

a) narcosis
b) respiratory depression
c) constipation
d) vomiting

A

respiratory depression

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14
Q

which traditional opioid receptor has the strongest link with physical dependance?

a) o
b) u
c) K
d) ORL-1

A

u

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15
Q

Which of the following is a mu (u) antagonist and K agonist?

a) nalbuine
b) buprenephrine
c) morphine
d) nalaxone

A

nalbupine

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16
Q

which of following is a mu (u) agonist and K antagonist?

a) nalorphine
b) bupenephrine
c) morphine
d) naloxone

A

bupenephrine

17
Q

a fetus will manifest the following after birth from a heroin addict what?

a) withdrawal symptoms
b) constipation
c) blededing
d) normal

A

withdrawal symptoms

18
Q

anaesthetic potency is direcly related with

a) lipid solubility
b) blood solubility
c) lung distribution
d) blood tissue partition coefficient

A

lipid solubility :)

19
Q

Which of the following agents is most potent?

a) Isoflurane, 0.77
b) unknown drug, MAC 1.7
c) methoxyflurane, MAC, 0.16
d) nitrous oxide, MAC 104

A

Methoxyflurane MAC 0.16 :)

20
Q

Based on the oil:gas partition coefficient which agent is more potent?

a) isoflurane, 98,
b) unknown drug, 47
c) methoxyflurane, 970
d) nitrous oxide, 1.4

A

methoxyflurane , 970

21
Q

patients limbs are limp after giving sevoflurane. which mechanism can explain this?

a) activation of NaCh receptors
b) inhibition og GABAa receptors
c) activation of voltage gated Na channels
d) inhibition of NaCH receptors

A

inhibition of nACH receptors

22
Q

based on blood:gas partition coefficient, which agent provides the fastest recovery time

a) sevoflurane, 0.6
b) enflurane, 1.9
c) halothane, 2.4
d) ether, 12.0

A

sevoflurane, 0.6

23
Q

based on the blood:gas coefficient, which agent provides the fastest induction time?

a) sevoflurane, 0.6
b) halothane 2.4
c) enflurane 1.9
d) ether 12.0

A

sevoflurane 0.6

24
Q

which seizure type is associated with T type Calcium channel?

a) simple partial seizures
b) absence seizures
c) complex partial seizures
d) grand mal seizures

A

absence seizures

25
Q

which anti epileptic drug is considered first line for petit mal?

a) ethosuximide
b) valproic acid
c) carbamazepine
d) diazepam

A

ethosuximide

26
Q

how do anti epileptics decrease neuronal excitability?

a) increase Ca mediated nt release
b) inhibition of GABA A receptor
c) increased GABA transaminase activity
d) inhibit glutamate synthesis

A

inhibit glutamate synthesis

27
Q

which anti epileptic drug has the least atogenic potential?

a) carbamazepine
b) valproic acid
c) phenytoin
d) phenobarbitone

A

phenytoin

28
Q

A patient is taking phenytoin and oestrogen. what will happen to the estorgens blood levels?

a) increase
b) decrease
c) noeffect

A

decrease

Pharmacology 1 (22 decks)

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