Mast Cell Tumors

Question 1

Pratschke, JAVMA, 2013:
Modified proportional margins

1. What % were cutaneous and what % were subcutaneous MCT?
2. What % were Kiupel low grade and what % were Kiupel high grade?
3. What % were excised with clear margins using the modified proportional margins approach?

Answer 1

Pratschke, JAVMA, 2013:

1. 87% cutaneous, 13% subcutaneous
2. 90% Kiupel low grade, 10% Kiupel high grade
3. 85% excised with clear margins using the modified proportional margins approach

Question 2

Kry and Boston, Vet Surg, 2014:
Primary re-excision vs radiation therapy for incomplete or close surgical excisions

1. Dogs that underwent re-excision or radiation therapy had significantly longer MSTs - true or false?
2. Local recurrence rates for re-excision group vs radiation therapy group vs no additional therapy?
3. Was adjunctive chemotherapy associated with improved survival or local control?
4. What % developed metastatic disease?

Answer 2

Kry and Boston, Vet Surg, 2014:

1. True
2. Local recurrence rates: 13% for re-excision group, 8% for radiation therapy group, 38% without additional therapy
3. No, chemo was not associated with improved survival or local control
4. 28% developed metastatic disease

Question 3

Stefanello, JAVMA, 2015:
Histologic grading

1. What % of Patnaik grade 2 MCTs were classified as Kiupel high grade MCTs?
2. What % of Kiupel low grade MCTs developed metastatic disease?

Answer 3

Stefanello, JAVMA, 2015:

1. 16% of Patnaik grade 2 MCTs were classified as Kiupel high grade MCTs
2. 15% of Kiupel low grade MCTs developed metastatic disease

Question 4

Risselada, JAVMA, 2015:
Surgically planned vs histologically measured lateral tumor margins

Mean histologic margins were what % smaller than the surgical margins?

Answer 4

Risselada, JAVMA, 2015:

Mean histologic margins were 35-42% smaller than the surgical margins

Question 5

Sanchez, JAVMA, 2017:
Diphenhydramine hydrochloride during MCT excision

1. Effects on mean and diastolic arterial blood pressures?
2. Any benefits?

Answer 5

Sanchez, JAVMA, 2017:

1. Mean and diastolic arterial blood pressures were significantly lower
2. No benefits

Question 6

Moore, VRU, 2017:
Spinal MCTs

1. Clinical signs of spinal MCT?
2. Location of spinal MCTs (extradural vs intradural-extramedullary vs intramedullary)?

Answer 6

Moore, VRU, 2017:

1. Paraspinal hyperesthesia, subacute progressive or acute myelopathy
2. Extradural

Question 7

Hughes, VRU, 2019:
Abdominal CT for staging

1. What % had metastasis based on liver and/or spleen aspirates?
2. Association between CT evaluation of the liver and cytological evaluation?

Answer 7

Hughes, VRU, 2019:

1. 10% were positive for metastasis from liver and/or spleen aspirates
2. CT evaluation of the liver showed no consistent pattern associated with mast cell metastasis and did not predict cytology results