Bone Healing and Fracture Nonunion Flashcards

1
Q

Akagi, VCOT, 2013:
Autogenous cancellous bone and FGF-2 combined with frozen allografts in femoral nonunions

Callus formation?

A

Akagi, VCOT, 2013:

Callus formation was not remarkable

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2
Q

Minier, VCOT, 2014:

Bone regeneration in rhBMP-2 constructs vs cancellous bone autograft constructs?

A

Minier, VCOT, 2014:

Bone regeneration appeared to develop earlier in the rhBMP-2 constructs than the cancellous bone autograft constructs but similar results were obtained at 20 weeks post-op

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3
Q

Might, VCOT, 2016:

Hydrogels appeared to prevent bone growth and even caused bone lysis - true or false?

A

Might, VCOT, 2016:

True

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4
Q

Massie, VCOT, 2017:
Nonunions treated with fixation, compression resistant matrix and rhBMP-2

  1. Minor complication rate?
  2. Major complication rate?
  3. Functional outcomes?
  4. There was a delay in healing in what types of fractures?
  5. What was most apparent at 3-5 days post-op?
A

Massie, VCOT, 2017:

  1. 73% minor complication rate
  2. 18% major complication rate
  3. 82% returned to full function, 18% had acceptable function
  4. Delay in healing in humeral condylar fractures compared to diaphyseal fractures
  5. Significant inflammation and swelling were most apparent at 3-5 days post-op
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5
Q

Field and Ruthenbeck, VCOT, 2018:

  1. Pattern of optical density measures during fracture healing?
  2. Correlation between optical density measures and the qualitative measure of bridging callus and the radiographic union score for tibial fractures (RUST)?
A

Field and Ruthenbeck, VCOT, 2018:

  1. Optical density measures decreased through 4 weeks post-op (resorptive phase) and then gradually and consistently increased at 8-16 weeks post-op
  2. Optical density measures showed strong correlation with measures of bridging callus and RUST
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