March 15 test 3

Question 1

Normal-appearing female with female external genitalia, scant sexual hair, rudimentary vagina; uterus and fallopian tubes absent–46 XY karyotype and pt develops normal functioning testes with high testosterone, estrogen and LH?

Answer 1

Androgen insensitivity syndrome–46XY

Question 2

Important features of benign reactive lymph nodes

Answer 2

• Palpable, tender lymphadenopathy
• Preserved lymph node architecture
• Multiple large germinal centers
• Recognizable light and dark zones
• Frequent mitoses
• “Tingible body macrophages”: macrophages containing debris from ingested lymphocytes

Question 3

What Coagulation disorder is associated with CF?

Answer 3

Vitamin K deficiency–PT and PTT will be increased

-This is due to malabsorption of fat soluble vitamins

Question 4

What is deficient in marfan syndrome

Answer 4

Fibrillin–which is a component of microfibrils

Question 5

What are the lab findings seen with Paget disease of been?

Answer 5

Normal serum Ca, phosphorus and PTH

Increased alkaline phosphatase –due to increased osteoblastic activity

Question 6

What is the primary cell type responsible for wound contracture?

Answer 6

Myofibroblasts

Question 7

Increased white-cell count with a left shift almost always means an?

Answer 7

Extracellular bacterial infection

Question 8

Lymphocytosis is seen with?

Answer 8

Intracellular bacterial infections and viral infections

Question 9

How is secondary polycythemia differentiated from primary?

Answer 9

Secondary has elevated EPO and primary has decreased EPO

Question 10

What are the clinical findings seen with Struge-Weber syndrome?

Answer 10

Nevus flammeus--on face/scalp
Ipsilateral leptomeningeal angiomatosis
Glaucoma
MR, Seizures, and hemiparesis
Pheochromocytoma

Question 11

DIC is associated with what type of necrosis in the kidney?

Answer 11

Diffuse renal cortical necrosis

Question 12

What are the 3 findings seen with aortic stenosis with respect to LV function and cardiac tissue?

Answer 12

• Increased left ventricular pressure and increased left ventricular work
• Increased left ventricular oxygen consumption and decreased cardiac tissue oxygen concentration
• Increased adenosine in cardiac tissue

Question 13

What are the 4 common causes of target cells in peripheral blood smear?

Answer 13

Hemoglobin C disease
Asplenia
Liver disease
Thalassemia

HALT–said the hunter to his target

Question 14

What is the most common predisposing factor the ectopic pregnancy?

Answer 14

PID

Question 15

What are the 2 clinical significant breast abnormalities seen in males?

Answer 15

Gynecomastia–most commonly seen in teenagers and younger men due to hormonal changes

Breast cancer–occurs in older men and resembles ductal carcinoma

Question 16

What are the findings seen with Meigs syndrome?

Answer 16

Triad:

• Ovarian fibroma
• Ascites
• Hydrothorax

“Pulling” sensation in groin

Question 17

What is the cause of retinopathy of prematurity caused by supplemental O2 given for tx of neonatal RDS?

Answer 17

Inappropriate vascular proliferation

Question 18

What is a marker used for dx of rhabdomyosarcoma?

Answer 18

DesMin

Question 19

What is the most serious complication of a complete hydatidiform mole?

Answer 19

Choriocarcinoma

Question 20

Tender, enlarged thyroid, with fever and transient hyperthyroidism that resolves in 2-4 months

Answer 20

Subacute granulomatous thyroiditis

Question 21

What type of seizures is often called a “drop” seizure and can be confused with fainting?

Answer 21

Atonic seizure–get loss of muscle tone

Question 22

Highly malignant cerebellar tumor that occur most commonly in children and is positive for GFAP?

Answer 22

Medulloblastoma –has both neuronal and glial differentiation

Question 23

Lymphoid neoplasm that is characterized by pancytopenia and stains positive for tartrate-resistant acid phosphatase (TRAP)?

Answer 23

Hairy-cell leukemia (HCL)