March 14 test 2

Question 1

What drugs are used for parkinson dz that inhibit metabolism of DA?

Answer 1

Selegiline and rasagiline–selectively inhibit MAO-B to increase DA availability

Question 2

What immunosuppressant is used for kidney transplant rejection prophylaxis that binds to the IL-2 receptor on activated T-cells?

Answer 2

Daclizumab and basiliximab–monoclonal antibodies

Question 3

What oral hypoglycemic drug is contraindicated in pts with HF and what is it MOA?

Answer 3

Thiazolidinediones–Pioglitazone/Rosiglitazone

–increase insulin sensitivity in peripheral tissue by binding to PPARg nuclear transcription regulator

Question 4

How is t 1/2 of a drug calculated?

Answer 4

0.7x Vd/ CL

Question 5

What is the 1st line tx for acute cholecystitis?

Answer 5

3rd generation Cephalosporin + metronidazole

Question 6

What diuretic should be avoided in patients with hyperparathyroidism due to its ability to reabsorb Ca++?

Answer 6

Thiazides–enhance reabsorption of Ca++ in the distal convoluted tubule

Question 7

What drug is contraindicated in pts with WPW?

Answer 7

Digoxin –can enhance transmission of impulses through accessory pathways by reentry or possible triggered membrane activity–leading to rapid ventricular rate or VFib

Question 8

What diuretics are contraindicated in pts with sulfa allergy?

Answer 8

Thiazides and loops

Question 9

What is Methimazole used for and what is a major side effect of it and how is it treated?

Answer 9

Similar to PTU and is used for hyperthyroidism

–can cause agranulocytosis–drug should be d/ced and pt should be given granulocyte colony-stimulating factor

Question 10

What two antihypertensive drugs can cause dyslipidemia?

Answer 10

Metoprolol and thiazides

Question 11

What drug used for chronic myelogenous leukemia (bcd-abl fusion) is associated with development of ascites, pulmonary effusion, pulmonary and peripheral edema and hepatotoxicity?

Answer 11

Imatnib

Question 12

What receptors are in the uterus?

Answer 12

Alpha 1 and Beta 2

Question 13

What is the only diuretic that will increase Na+ delivery to the macula densa and cause constriction of the afferent arterioles of the kidney?

Answer 13

Acetazolamide

Question 14

What drug is used for tx of BPH and male pattern baldness and what is the MOA?

Answer 14

Finasteride–5a-reductase inhibitor–decreases the conversion of testosterone to DHT

Question 15

What is the mechanism of action of benzodiazepines?

Answer 15

Facilitate GABAa action by increasing frequency of Cl- channel opening

Question 16

What alkylating agent cross-links DNA at guanine N-7 and what is its major side effect?

Answer 16

Cyclophosphamide

-Hemorrhagic cystitis

Question 17

Indicated for the management of secondary hyperparathyroidism in patients with chronic kidney disease and the treatment of hypercalcemia in patients with parathyroid carcinoma

Answer 17

Cinacalcet-a calcimimetic agent that increases the sensitivity of the parathyroid calcium-sensing receptor to calcium. This causes a reduction in PTH

Question 18

What is used to prevent pneumonia caused by RSV infection in premature infants?

Answer 18

Palivizumab