March 15 test 2

Question 1

Pyrimidine analog antimetabolite that interferes with DNA and RNA synthesis and is used for colon and pancreatic cancers?

Answer 1

5-Fluorouracil–analog of thymine (DNA) and uracil (RNA)

Question 2

What is the MOA of methamphetamine?

Answer 2

Causes release of DA and NE which cause reinforcing effects and increased BP/HR, respectively

Question 3

What drugs are commonly associated with hyperprolactinemia–causing amenorrhea, galactorrhea, and gynecomastia?

Answer 3

Haloperidol
Fluphenazine
Risperidone

Question 4

What are the presenting symptoms of serum sickness reaction and what is the tx?

Answer 4

Fever, pruritus and arthropathy

Tx: antihistamines and corticosteroids

Question 5

What is the MOA of cyclosporine?

Answer 5

Complexes with cyclophilin and inhibits calcineurin–which decreases the production of IL-2

Question 6

What 2 B-blockers are CI in angina and HF due to their intrinsic sympathomimetic activity and do not cause significant decrease in HR and maintains a high myocardial O2 consumption?

Answer 6

Pindolol and Acebutolol–have partial agonist activity

Question 7

What are the side effects of lithium?

Answer 7

LMNOP
Movement-tremor
Nephrogenic DI
HypOthyroidism
Pregnancy problems--Ebsteins anomaly--malformed tricuspid valve

Question 8

What diuretics are CI with an AKI and why?

Answer 8

K-sparing diuretics–because with an AKI volume overload, hyperkalemia, metabolic acidosis, hypocalcemia , and hyperphosphatemia can all occur and K sparing diuretics can cause hyperkalemia and cause metabolic acidosis to worsen

Question 9

What is efficacy of a drug

Answer 9

Maximal effect a drug can produce

Question 10

What is associated with a rapid onset of severe pain and profound visual loss with “halos around lights.” The eye appears red with a steamy cornea and dilated pupil, and feels hard to palpation and what is used for tx and MOA?

Answer 10

Angle-closure glaucoma

Acetazolamide is a carbonic anhydrase inhibitors indicated for the treatment of acute episodes of angle-closure glaucoma.
Acetazolamide decreases the production of aqueous humor.

Question 11

What drug would be useful in a patient with hypokalemia and ankle edema.

Answer 11

K-sparing diuretic

Question 12

What is a non steroidal competitive inhibitor at androgen receptors and used for prostate carcinoma?

Answer 12

Flutamide

Question 13

What antimetabolite is a Pyrimidine analog and inhibits DNA polymerase and is used for AML and lymphomas?

Answer 13

Cytarabine–Causes panCYTopenia

Question 14

What class of drugs can cause all degrees of AV heart block?

Answer 14

B-blockers

Question 15

What muscle relaxant has anticholinergic side effects?

Answer 15

Cyclobenzaprine

Question 16

What oral hypoglycemic drug class is CI in pts with sulfa allergy?

Answer 16

Sulfonylureas–Gl…ides and amides

Question 17

Ester local anesthetics have ____ and Amides and _____. If pt is allergic to one give the other

Answer 17

One/no i

Two i’s