March 13 test 1 Flashcards
MOA of Vincristine and vinblastine?
Bind B-tubulin and inhibit its polymerization into microtubules
What chemo agent has the major side effect of peripheral neuropathy?
Vincristine
What are the clinical features of multiple myeloma–a monoclonal neoplastic proliferation of plasma cells?
C-HyperCalcemia
R-Renal involvement
A-Anemia
B-Bone lytic lesions/Back pain
What are the 2 causes of ATN?
Ischemic or Nephrotoxic injury
What antihistamines should be avoided when pt has BPH?
First generations that have antimuscarinic effects–Diphenhydramine, dimenhydrinate, and chlorpheniramine
What disease is diagnosed by urinary cyanide-nirtoprusside test?
Cystinuria–hereditary defect of renal PCT and intestinal amino acid transporter that prevents reabsorption of Cystine, Ornithine, Lysine, and Arginine–COLA
–Formation of Hexagonal cystine stones
Most common bilateral ovarian tumor lined by surface epithelium filled with clear fluid?
Serous cystadenoma
What disease is associated with Reed-Sternberg cells?
Hodgkin lymphoma
What vasculitis is associated with Hep B and C infection?
Polyarteritis nodosa
What are the 5 p’s of acute intermittent porphyria?
Painful abdomen Port-wine colored urine--coporphobilinogen Polyneuropathy Psychological disturbances Precipitated by drugs, ETOH, starvation
Formation of hyaline membranes within the alveolar cavities…
Diffuse alveolar damage
Associated with deletion of VHL gene on Ch. 3p, hemangioblastomas and 1/2 pts have bilateral renal cell carcinoma?
Von Hippel-Lindau syndrome
Paralysis of conjugate vertical gaze due to lesion in superior colliculi?
Parinaud syndrome–caused by stroke, hydrocephalus, pinealoma
What is seen in the urine of pt with multiple myeloma?
Ig light chains–Bence Jones proteins
Tumor located at cortical gray/white matter junction is indicative of….
Metastasis
