Management of Opiate Misuse Flashcards

1
Q

What medical intervention is used to combat addiction?

A
  • Replacement prescribing.
  • Detoxification and relapse prevention.
  • Benzodiazepines.
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2
Q

What psychosocial intervention may be used to combat addiction?

A
  • Keyworking.
  • Therapeutic alliance.
  • Self-alliance.
  • Self-help.
  • Contingency management (paying people to stop).
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3
Q

When is detox suitable?

A

If history of opiate misuse is shorter and uncomplicated

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4
Q

What type of person is detox suitable in?

A

Someone who is stable socially

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5
Q

When only does detox work?

A

Person is detoxing TO (not FROM) something

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6
Q

What is used only in impulsive relapsers?

A

Opiate blockage

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7
Q

Give an example of an opiate blocker.

A

Naltrexone

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8
Q

What 4 detox options are available?

A
  1. Self-detoxification (with support).
  2. Reducing prescribed opioids.
  3. Alpha-2-adrenergic agonists.
  4. Adjunctive treatments.
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9
Q

Outline how reducing prescribed opiates is done.

A
  • Use current drug OR consider alternative.

* Gradual reduction; time-limited process; psychosocial support; symptom Rx.

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10
Q

Give an example of an alpha-2-adrenergic agonist.

A

Lofexidine

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11
Q

What does Lofexidine do?

A

Reduces physical symptoms

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12
Q

Describe the dosing of Lofexidine.

A

Initial test done, then maximise dosage to overcome sx.

Later, tailor dose down

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13
Q

Give examples of adjunctive treatments.

A

Loperamide.
Hypnosis.
NSAID.

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14
Q

OST

A

Opiate Substitute Therapies

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15
Q

Give 2 examples of opiate substitute therapies.

A

Methadone
OR
Buprenorphine

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16
Q

What is the risk for patients on OST?

A

Poly drug use (plus alcohol) and drug death

17
Q

In terms of mode of action, what type of drug is Buprenophine?

A

A partial antagonist

18
Q

What is the main issue with Buprenorphine?

A

Issue of supervision – it is a sublingual tablet which takes 15mins to dissolve, so prescribing pharmacist needs to be with each pt for this length of TIME

19
Q

What can Buprenorphine be used in combination with?

A

Naloxone

20
Q

What can be done (that isn’t usually done in the UK) if OST fails?

A

Heroin assisted treatment (HAT)

21
Q

Who is HAT usually used for?

A

Those at risk of harm (PWIDs) who are failing on traditional treatments

22
Q

What are higher doses of OST-M better for?

A

Retaining patients and reducing opiate and cocaine use