Male reproductive Flashcards

1
Q

Cause:
-Testis do not descend normally into ______
-Usually retained in ______; sometimes in ______
-Germ cells require a ______-than-normal body temperature
-______ cells function normally at body temperature
Manifestations:
-______ destroyed at higher intra-abdominal temperature,
______ function normally
-Undescended testis more prone to developing ______
-Treatment : ______ replace testis in scrotum

A
Cryptorchidism
scrotum
abdominal cavity
inguinal canal
lower
Interstitial
Germ cells
Interstitial cells
testicular cancer
Surgically
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2
Q
  • development of penis takes place between 9 and 12 weeks of pregnancy occurs in 1 out of every 150-300 boys. It is a condition where the ______ does not form completely at the tip of the penis, instead it can be located ______ along the penis.
    -Hypospadias is an anomaly in which the urethral meatus opens on the ____ surface of the penis
    -Epispadias is an anomaly in which the urethral meatus opens on the ______ surface of the penis. It is less common than hypospadias.
    -Causes: Less ______ production, No conversion of ______ from ______, Androgen receptor deficiency.
    -______ – 16% also have Hypospadias
    -Treatment: Never ______ a child without checking for hypospadias because the foreskin is essential for the repair.
    It can be corrected ______ using the foreskin.
A
hypospadias/epispadias
urethral opening
anywhere
ventral
dorsal
androgen
DHT
testosterone 
Cryptorchidism
circumcise
surgically
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3
Q

-description: it is a chromosomal disorder. Children are born with an extra sex chromosome, which is known as ______. These children present a significant ______ and ______ delay, which requires formalized speech and language program.
-Chromosome Variation: Normal male 46 XY and Klinefelter’s Syndrome has ______ (one in 600) and also called ______ (one in 900).
-it is more common the down’s syndrome and cystic fibrosis and very poorly understood
SYMPTOMS:
-Individuals are male with different degree of 1 ______
-Decrease secretion of ______ (FSH & LH).
-______ size gonads, which affect the ______ function.
-______ (breast development)
-______ (absence of sperm)
-Common symptoms with school age Children:
-______ 5th finger, decreased muscle tone, delayed ______ development, delayed speech & language skills, ______ legs and arms, hand tremors and mild to severe developmental delays.
-Treatment: ______ with Testosterone.

A
klinefelter's syndrome
sex chromosome variations (SCV)
speech
language
47,XXY
pseudohermaphrodite
Hypogonadism
gonadotropins
Smaller
testicular
Gynecomastia
Azoospermia
Curved
pubertal
long
Hormone replacement therapy (HRT)
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4
Q

cause:
-abnormal attachment of testis in scrotum
-predisposes to rotary ______ of _____ and _______
-shutting off _____ to testis
manifestations and treatment:
-acute onset of _____ pain and ______
-leads to ______ unless promptly untwisted

A
Testicular Torsion
twisting
testis
spermatic cord
shutting off blood
testicular
swelling
hemorrhagic infarction
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5
Q

Scrotal Abnormalities

  • ______:
  • exces fluid accumulates in ______
  • treated by ______ or ______ of tunica vaginalis
  • ______:
  • ______ in spermatic cord
  • usually ______ side of scrotum involved
  • may impair ______
  • No treatment required unless causes ______ or impairs _______
A
hydrocele
spermatic cord
aspiration
resection
varicocele
varicose veins
left
discomfort
fertility
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6
Q
  • defined as failure to achieve an erection of the penis. The causes of ED are still unknown.
  • Erection is controlled by ______. Vasodilatation of penile arteries (______ and ______) builds up ______, which causes erection.
  • Some of the factors responsible for Erectile Dysfunction:
    1. Drugs (______) e.g. Digoxin
    2. Psychological problems
    3. Distortion of the ______ or tissue
    4. ______ related liver damage, which interferes with ______ production.
    5. Diabetic patients.
    6. ______
A
erectile dysfunction or impotence 
parasympathetic nervous system
Corpus Cavernous
Spongiosum
blood
β-Blockers
penile arteries
Alcohol
Testosterone
Smoking
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7
Q

is a persistent and painful erection of penis. It is also caused by ______ of the soft erectile tissue. Drugs like ______ are known to cause this condition. Recreational of Viagra or Cilias will also cause this.

A

priapism
fibrosis
opium

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8
Q

______, is condition caused by ______, presents as a soft, painful ______. This ulceration makes the site more prone to ______ with other organisms or fungi, with the tendency to spread along the penis and groin areas.

A

Chancroid
Haemophilus ducreyi
ulcer
infection

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9
Q

Syphilis: clinical stages

  • primary stage: ______, hard ______ (anindurated ulcer) often at the ______, or site of infection. Because this first stage is painless, the patient may not know he has the disease, and could proceed to infect other people.
  • secondary stage: ______ number of organisms in the body, manifesting in a diffuse rash of ______, included on the ______, ______ and membranes.
  • tertiary stage: ______ form (which are basically granulomas with giant cells, inflammation of the vessels and necrosis). If this stage is left untreated, the infection may progress to involve the ______ and ______; occurs 2 to 20 years later.
  • diagnostic tests:
    1. demonstration of ______ in chancre
    2. ______ tests (antigen-antibody reactions in a test tube)
  • treatment: ______
A
painless
chancre
glans
largest
small red macules
palms
soles
gummas
heart
nervous system
treponemas/spirochetes
Serologic
antibiotics
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10
Q

sexually transmitted diseases: Gonorrhea
______ infection: one of the cause for pelvic inflammatory disease (PID).
clinical manifestations:
1. ______ (inflammation of passage through which urine is discharged from bladder)
2. ______ (inflammation of cervix)
3. ______ (inflammation of pharynx)
4. Infection of ______ (proctitis)
-diagnosis: ______ of organisms from sites of infection
-Treatment: ______

A
Neisseria gonorrhoeae
Urethritis
Cervicitis
Pharyngitis
rectal mucosa
Culture
Antibiotics
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11
Q

sexually transmitted diseases: Chlamydia

  • ______ is the most common STD . #2 cause of PID.
  • Clinical symptoms: ______ & ______. It can also cause epididymitis. Chlamydial infection should be suspected when bacteria are not demonstrated in a ______ discharge
  • Diagnosis: Detection of chlamydial _______ cervical/urethral secretions or Cultures.
  • treatment: ______
A
Chlamydia trachoma's
Cervitis
Urethritis
purulent urethral 
chlamydial 
antibiotics
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12
Q

sexually transmitted diseases: herpes

  • ______ infection accounts for the majority of genital herpes cases (although HSV type 1 is also capable of causing genital infections) and is spread by ______.
  • HSV infection produces ______ and ______ that can involve the cervix, vagina, clitoris, vulva, urethra, and perianal skin.
  • ______ with viral inclusions are found in cytologic smears from lesions.
  • Pathologic/histologic findings are cells with the three “Ms”: ______, ______, and ______.
A
HSV type 2
sexual contact
small vesicles
shallow ulcers
multinucleated giant cells
multinucleation, nuclear molding, and margination of the chromatin
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13
Q
  • The cause is Calymmatobacterium (Donovania) granulomatis, a gram-______ rod. Transmission is probably ______.
  • ______, which are multiple organisms filling large histiocytes, are characteristic.
  • an infection appears initially as a papule, which becomes ______. It progresses by adjacent lesions to form large______ or ______ ulcerations, sometimes with lymphatic obstruction or genital distortion.
A
Granuloma Inguinale
negative
sexual
Donovan bodies
superficially ulcerated
genital
inguinal
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14
Q

typical vulvovaginitis, with profuse, foul-smelling purulent frothy discharge

A

trichomoniasis (yeast infection)

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15
Q
  • ______: When bacterial, it is often associated with epididymitis. may be caused by _____
  • when viral, most often due to ______. Bilateral, orchitis may result in ______ due to atrophy of the ______. Serum testosterone is ______, whereas pituitary follicle- stimulating hormone and luteinizing hormone are ______.
  • ______: Common than orchitis. Causes most often include: ______, ______, _______& ______
A
inflammation of testes
orchitis
syphilis 
mumps virus
sterility
seminiferous tubules
decreased
increased
Epididymitis
Neisseria gonorrhoeae
Chlamydia trachoma's
E.coli
mycobacterium tuberculosis
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16
Q

tumors of the testis

  • These are rare tumors but important because they affect men ______ years of age.
  • most tumors are of ______ origin
  • most tumors are ______ but can be successfully treated by ______ combined with ______ or ______ therapy.
  • Mortality was high before, but now more than 90% of patients survive.
A
25 to 45
germ cell
malignant
surgery
chemotherapy 
radiation
17
Q

serum markers for testicular cancer

  • ______, or HCG, is usually synthesized and secreted by the placental syncy- tiotrophoblast.
  • ______ (AFP) is the major serum protein of the early fetus and is synthesized by the fetal ______, ______, and ______. It is usually undetectable after the first year of life.
  • ______ is useful in following the tumor burden, since its level is proportional to the mass of tumor cells. However, it is produced in a number of tissues, so increased levels are not specific for testicular tumors.
A
Human chorionic gonadotropin
Alpha-fetoprotein
gut
liver cells
yolk sac
LDH (lactate dehydrogenase)
18
Q

germ cell tumors of the testis

  • ______: These are the most common type of germ cell tumor. The occurrence peaks in men in their 30s, and account for about half of the germ cell tumors. Made of ______. Better prognosis than NSGCT. Seminomas are ______ tumors which can grow to ten times the size of a normal testicle. They do not secrete markers. It does not ______ on a flash light.
  • ______ (NSGCT): are more malignant than seminmoas. ______ occurs in early stages. Secretes ______ & ______. Treatment includes surgery, abdominal ______ and chemotherapy.
A
Seminomas
single cell
large
transiluminate
Nonseminomatous germ cell tumor
Metastasis
AFP & hCG
lymph node dissection
19
Q

nonseminomatous germ cell tumor

  • ______: These are more aggressive than seminomas and generally occur in 20-30 year olds.
  • ______ are a highly malignant form of testicular tumor that is composed of ______. It is the most aggressive of the NSGCT. It is more likely to be found as a component of a mixed germ cell tumor. These tumors are usually ______ and are found by palpation of a ______. Testicular enlargement is rare, but ______ & ______ common.
A
Embryonal carcinomas
Choriocarcinomas
mixed germ cells
small
small testicular nodule
hemorrhage
necrosis
20
Q

the tumor consists of a random arrangement of ______ (muscle, cartilage, adipose tissue), ______ (neural tissue, skin), and ______ (gut, bronchial epithelium) tissue. Mature teratomas are found in adults and immature teratomas are found in children.

A

teratoma
mesodermal
ectodermal
endodermal

21
Q

sex cord tumors: not common

  • ______: hormone synthesis increases
  • ______: May produce androgen or estrogen which cause ______ or ______
A

leydig cell tumor
sertoli cell tumor
masculinization
feminization

22
Q

clinical stages of testicular cancer

  1. stage I means the tumor is ______ to the ______, ______, or ______
  2. Stage II cancer means distant spread is limited to ______ below the diaphragm.
  3. Stage III cancer means there is metastasis outside the ______ or ______ the diaphragm
A
confined 
testis
epididymis
spermatic cord
retroperitoneal lymph nodes
peritoneal nodes
above
23
Q
  • ______ is the most frequent cause of urinary tract obstruction. BPH is extremely common (almost universal) in older men.
  • BPH is directly related to the action of ______, a testosterone metabolite. DHT is synthesized from testosterone by the action of ______, type __, and ______ of this enzyme is one approach to the treatment of BPH.
  • BPH is characterized grossly by a ______ of the gland, affecting the inner groupings of glands (______ and ______ zones.)
  • BPH may also be caused by an ______ in ______ (estrogens promote expression of receptors for DHT).
  • Diagnosis: Increased total ______ with proportional increase in ______.
  • Treatment: ______ (5α-reductase inhibitor) or ______, α-blockers, ______ (transurethal resection of prostate).
A
BPH (benign prostatic hyperplasia)
dihydrotestosterone (DHT)
5α-reductase
2
inhibition
rubbery, nodular enlargement
periurethral
transitional
age-related increase
estrogens
PSA (prostatespecific antigen)
free PSA
Finasteride
Cialis
TURP
24
Q
  • This is the most common cancer of internal organs in males—more than 100,000 new cases per year.
  • This is the third most common cause of cancer- related deaths in males.
  • t is a tumor of old age, and the prolongation of human life has been accompanied by an overall increased incidence of prostate carcinoma.
  • no effective treatment exists
A

carcinoma of the prostate

25
Q

prostate carcinoma
-the cause remains ______
-no major risk factors have been identified
-hormonal influences: ______ plays a role in the pathogenesis
-Incidence among americans of various origin is as follows: African > European > East Asian.
-the course may be ______ or ______; this can be predicted by the very useful ______, based on differentiation. The tumor is often well differentiated with small invasive glands with prominent ______.
-The tumor arises most often from the ______ of glands. Diagnosis is most often by ______
DIAGNOSTIC TEST:
-Prostate cancer is associated at an early stage with an increase in serum ______. Elevations of PSA reflect a complexed form (bound to ______), which becomes elevated with prostatic cancer, and a free form, which increases with BPH. Thus, an increased ______ with a decreased fraction of ______ suggests malignancy.
-A number of approaches to PSA measurement (e.g., ______ PSA, PSA ______, PSA ______) are used to ______ the predictive value of this procedure.
-prostate cancer is characterized by increased ______ when the tumor penetrates the capsule into ______
-treatment: ______, radiotherapy, ______ system, ______, ______ and chemotherapy.

A
unknown 
testosterone 
indolent
aggressive
Gleason system of grading
nucleoli
peripheral group
rectal examination 
PSA
α1-anti-chymotrypsin
total PSA
free PSA
serial
velocity
density
increase
serum prostatic acid phosphatase
adjacent tissues
Prostatectomy
da Vinci Si robotic
GnRH analogues
anti-androgens
26
Q
  • This is rare in the US, affecting 1 to 2 men per 100,000.
  • it is more common in some parts of the world, like south america
  • tumors are ______ carcinomas
  • metasteses occur first to ______
  • prognosis depends on ______ of tumor
  • treatment: ______
A
carcinoma of the penis
squamous cell
inguinal lymph nodes
stage
surgery