Male Reproductive Flashcards
sertoli cells. Where is it located and what is its structure?
L: between basal lamina and lumen
S: nucleus irregular, elongated, prominent nucleolus
what is the function of sertoli cells?
- control hormones, nutrients to maintain environment for spermatogenesis
- protection of germ cells-blood testis barrier
- production of inhibin and activin, androgren binding protein and anti-mullerian hormone.
spermiogenesis
- formation of nuclear cap by golgi complex
- condensation of nucleus
- formation of flagellum
- rearrangement of mitochondria
- extensive shedding of cytoplasm
In the blood/testis barrier what does basal compartment and adluminal compartment contain?
B: spermatagonia and preleptotene primary spermatocytes
A:contains more advanced primary, secendary spermatocytes, spermatids and sperm
What is the role of blood/testis barrier?
- protection of microenvironment within adluminal compartment.
- haploid cells are genetically different from parent cells- may prevent foreign proteins from reaching general circulation and causing autoimmune infertility.
what is the role of androgen-binding protein?
FSH stimulates synthesis of ABP by sertoli cells= binds to testerone and increases it concentration within seminiferous tubules; promoting spermatogenesis.
leydig cells
produce testosterone
- prolactin increases the number of LH receptors in Leydig cells
- anabolic effects
- stimulates spermatogenesis
- programming CNS for male gonadotropin secretion
Where is rete testis located? why type of epithelium?
in mediastinum; simple cubodial epithelium
Seminiferous tubules and Tubuli recti (straight tubules) lined by and what type of epithelium?
ST: sertoli cells (terminal portion of seminiferous tubules
TR: simple cubodial epithelium (open into rete testis in the mediastinum)
What type types of epthelial cells make up ductuli efferentes?
noncilated cubodial cells with microvilli (absorptive cells) and cilated columnar cells
What is the 3 main components of intratesticular genital ducts? What is the general function?
tubuli recti, rete testis, ductuli efferentes
function: maturation of sperm, abosorption of luminal fluid and defective sperm
What is the function of ductus epididymus?
storage of sperm, absorption of fluid and maturation and inhibition of capacitation
what type of epithelium for ductus epididymus?
Smooth muscle thickness gradually increases in what range?
pseudostratified columnar epithelium with stereociliae.
-head to tail ( sperm maturation and storage in tail)
What are the components of Ductus Deferens (Vas deferens)? What type of epithelium is in the mucosa layer?
- mucosa: pseudostratified columnar epithelium, lamina propria with elastic fibers
- muscularis
- ampulla (thin sm)
- ejaculatory no smooth muscle.
In the Urethra, what type of epithelium is present in prostatic, membranous and penile portion?
prostatic: transitional
between prostate and penis: pseudostratified columnar
penile: pseudostratified columnar
Distal end: stratrified squamous
