Major Minerals Flashcards
Macrominerals Definition
greater than or equal to 0.01% BW
5g/60kg
greater than or equal to 100mg/d
List the macrominerals
Calcium
Phosphorus
Magnesium
Sodium
Potasium
Chloride
Calcium Sources
- Milk, cheese, yogurt
- Sardines & salmon with bones
- Clams & oysters
- Cruciferous vegetables: Turnip, mustard greens, broccoli, cauliflower, kale
- Tofu
- Fortified juices
Calcium Absorption is reduced by:
- Oxalate
- Phytate
- Phosphorus not likely to affect Ca
balance - Menopause
- Age
- Iron
Calcium Absorption increased by:
- Vitamin D
- Lactose
Calcium excretion increased by:
- Protein
- Sodium
- Caffeine
Calcium Supplements
- Citrate best absorbed
- Take carbonate with food
- ≤ 500 mg/dose
Calcium regulation by PTH and calcitriol
- low blood calcium signals the parathyroid gland to release PTH into the blood
- PTH binds to bone cells to trigger resorption or breakdown of bone minerals to release Ca into the blood
- PTH acts on the kidney to make calcitriol
- calcitriol plus PTH promote reabsorption of Ca in kidney and into blood
- Calcitriol travel to intestine and promote Ca absorption
Calcium Function (6)
Normal bone
intracellular messenger
Muscle contraction
Blood Clotting
Normal blood pressure
Colon cancer Prevention
Calcium function: normal bone
- 99% of Ca in bones and teeth
- Hydroxyapatite [Ca10(PO4) 6OH2] – bone crystals
- Peak bone mass achieved between 25-30 years
- Women lose bone at increased rate after menopause
Calcium function: Intracellular messenger
- Activates protein kinases (phosphorylations)
- Activates phospholipase A2
- Cyclic AMP activity – involved in cellular signaling
Calcium function: muscle contraction
- Ca enters muscle and binds to troponin-c
Calcium function: Blood Clotting
- Required for activation of clotting factors
Calcium function: Normal Blood Pressure
- Relaxation of smooth muscle (vasodilation)
Calcium function: Colon Cancer Prevention
- decrease precancerous polyps
Calcium Deficiency areas (3)
serum , bone, intake
Ca Deficiency low in serum
tetany- uncontrolled muscle contraction
Ca Deficiency low in bone
Rickets – children
* Osteoporosis – adults
Ca Deficiency low in intake
- Hypertension
- Colon caner
- Weight gain
Toxicity
- Hypercalcemia-soft tiissue
- Hypercalciuria- kiney stobe
inc Intake- Risk for prostate cancer
Hypercalcemia
- Soft tissue calcification
Hypercalciuria
- risk of kidney stones
Ca Assessment
- Serum calcium
- Serum ionized calcium
- Bone mass/bone density (DEXA)