Major blood groups Flashcards
Erythrocytes acquire this phenotype by adsorbing substances from the plasma, rather than being membraned-bound antigens
Lewis antigen
Le gene codes for what glycosyltransferase and adds what sugar adds up to its chain
L-fucosyltransferase
L-fucose —> Type 1
Antigens and antibodies in MNSs Blood groups system
📍MN antigen
Ss antigen
📍Anti-M
Anti-N
Anti-S and Anti-s
Anti-U
Differentiate MN antigens
✅Found in GLYCOPHORIN A (GPA)
✅M has serine and glycine
✅N has leucine and glutamic acid
✅Easily destroyed or removed by enzymes
Give identification for Ss Antigens
✅Located on GLYCOPHORIN B (GPB)
✅Amino acid at 29 on GPB
✅S has methionine
✅s has threonine
✅Less easily degraded by enzymes
Antigen and antibodies in P blood group system
📍P1 antigen
📍Anti-P1
Anti-PP1-Pk
Anti-P
Anti-Pk
P blood group:
Found on fetal red cells as early as 12 weeks, but it weakens with gestational age
P1 Antigen
P blood group:
Has been found plasma, and droppings of pigeons and turtledoves, as well as in the egg white of turtle doves
P1
P blood group:
has been identified in hydatid cyst fluid, extracts of Lumbricoides terrestris, and Ascaris suum
P1 antigen
P blood group:
📍 observed in individuals infected with HYDATID DISEASE
📍 Associated with fascioliasis, Clonorchis sinensis, and Opisthorchus viverrini infections
Anti-P1
P blood group:
📍Originally called ANTI-Tja
📍Associated with spontaneous abortions in early pregnancy
Anti-PP1-Pk
P blood group:
📍Naturally occurring alloantibody in the sera of all Pk individuals
📍PAROXYSMAL COLD HEMOGLOBINURIA
📍Demonstrated by the DONATH-LANDSTEINER TEST
Anti-P
I blood group:
📍Common autoantibody that can be benign or pathologic
📍Demonstrates string reactions with adult cells and weak reactions with cord cells
Anti-I
I blood group:
Found in the serum of many normal individuals
Benign Anti-I
I blood group:
Attach in vivo and cause autoagglutination and vascular occlusion (Raynaud’s phenomenon) or intravascular hemolysis
Pathologic Anti-I
