Chromosomal Locations of Major blood group systems

Question 1

Chromosome 1

Answer 1

Rh, Duffy

Question 2

4

Answer 2

MNS

Question 3

7

Answer 3

Kell

Question 4

9

Answer 4

ABO

Question 5

18

Answer 5

Kidd

Question 6

22

Answer 6

P1

Question 7

Possible genotypes

A1

Answer 7

A1A1, A1O, A1A2

Question 8

Possible genotypes

A2

Answer 8

A2A2, A2O

Question 9

Possible genotypes

A1B

Answer 9

A1B

Question 10

Possible genotypes

A2B

Answer 10

A2B

Question 11

Possible genotypes

B

Answer 11

BB, BO

Question 12

Possible genotypes

O

Answer 12

OO

Question 13

Glycosyltransferase of H antigen

Answer 13

L-fucosyltransferase

Question 14

Immunodominant sugar of H antigen

Answer 14

L-fucose

Question 15

Glycosyltransferase of A antigen

Answer 15

N-acetylgalactosaminyltransferase

Question 16

Immunodominant sugar of A antigen

Answer 16

N-acetyl-D-galactosamine

Question 17

Glycosyltransferase of B antigen

Answer 17

D-galactosyltransferase

Question 18

Immunodominant sugar of B antigen

Answer 18

D-galactose

Question 19

Glycosyltransferase of AB antigen

Answer 19

N-acetylgalactosaminyltransferase
D-galactosyltransferase

Question 20

Immunodominant sugar of AB antigen

Answer 20

N-acetyl-D-galactosamine
D-galactose

Question 21

Comparison of Type 1 and Type 2 chains:

Linkage: Beta 1,3

Answer 21

Type 1

Question 22

Comparison of Type 1 and Type 2 chains:

Beta 1,4

Answer 22

Type 2

Question 23

Comparison of Type 1 and Type 2 chains:

Origin of Type 1

Answer 23

Plasma

Question 24

Comparison of Type 1 and Type 2 chains:

Origin of type 2

Answer 24

Synthesized on erythrocytic precursors

Question 25

Comparison of Type 1 and Type 2 chains: controlling genes of Type 1

Answer 25

H, A, B, Se and Lewis

Question 26

Comparison of Type 1 and Type 2 chains: Controlling genes of Type 2

Answer 26

H, A, B

Question 27

Subgroups of A: A1

Answer 27

✅ Branched A antigens ✅ 2 million A antigen/adult red cells ✅ Positive with anti-A ✅ Positive with anti-A1 lectin

Question 28

Subgroups of A: A2

Answer 28

✅Linear A antigens ✅500,000 A antigens/adult red cells ✅Positive with Anti-A ✅Negative with anti-A1 lectin

Question 29

Other subgroups of A: Mixed field agglutination with anti-A and/or anti-AB

Answer 29

A3

Question 30

Other subgroups of A: Weak agglutination with anti-AB only

Answer 30

Ax

Question 31

Other subgroups of A: Less than or equal to 10% red cells show very weak mf agglutination

Answer 31

A end

Question 32

Other subgroups of A: No agglutination with anti-A and anti-AB, secretors demonstrates quantities of A substance in saliva

Answer 32

Am

Question 33

Other subgroups of A: No agglutination with anti-A and anti-AB, secretors contain small amount of A substance in saliva

Answer 33

Ay

Question 34

Other subgroups of A: No agglutination with anti-A and anti-AB, secretors contain only H substance and no A substance in saliva

Answer 34

A el

Question 35

Subgroups of B: mixed field agglutination with anti-B and/or anti-AB

Answer 35

B3

Question 36

Other subgroups of B: Agglutination with anti-AB (wk/0 with anti-B)

Answer 36

Bx

Question 37

Other subgroups of B: No agglutination with anti-B and anti-AB, secretors demonstrates quantities of B substance in saliva

Answer 37

Bm

Question 38

Other subgroups of B: No agglutination with anti-B and anti-AB, secretors contain only H substance and no B substance in saliva

Answer 38

Bel

Question 39

Rare phenotypes in which the RBCs are completely devoid of H antigens or have small amounts of H antigen present

Answer 39

Para-bombay

Question 40

RBCs of these individuals express weak forms of A and B antigens, which are primarily detected by adsorption and elution studies

Answer 40

Para-Bombay

Question 41

If a person is genetically A or B, the respective enzymes can be detected, but no H enzyme is detectable, even though it has been shown that there is limited production of H antigen on the RBCs

Answer 41

Para-Bombay

Question 42

Required antigens: 📍 Reported in persons of Type O or B in association with severe infections caused by Proteus mirabilis 📍Tn-activated erythrocytes

Answer 42

Acquired A Antigen

Question 43

Required antigens: 📍Associated with conditions as carcinoma of the colon or rectum, intestinal obstruction, massive infection of lower gastrointestinal tract, and septicemia caused by Proteus vulgaris

Answer 43

Acquired B antigen

Question 44

Acquired antigens: 📍Can also result from increased permeability of the intestinal wall and subsequent absorption of bacterial polysaccharide (Escherichia coli O86) on the erythrocyte

Answer 44

Acquired B antigen

Question 45

Give the characteristics of the blood group: A

Answer 45

✅IgM ✅Reacts at room temp ✅Naturally-occurring ✅Cannot cross the placenta

Question 46

Give the characteristics of the blood group: B

Answer 46

✅IgM ✅Reacts at room temp ✅Naturally occurring ✅Cannot cross the placenta

Question 47

Give the characteristics of the blood group: O

Answer 47

✅Predominantly IgG ✅Reacts at 37C ✅Immune antibody ✅Can cross the placenta