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ISBB!!!! > Chromosomal Locations of Major blood group systems > Flashcards

Chromosomal Locations of Major blood group systems Flashcards

1
Q

Chromosome 1

A

Rh, Duffy

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2
Q

4

A

MNS

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3
Q

7

A

Kell

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4
Q

9

A

ABO

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5
Q

18

A

Kidd

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6
Q

22

A

P1

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7
Q

Possible genotypes

A1

A

A1A1, A1O, A1A2

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8
Q

Possible genotypes

A2

A

A2A2, A2O

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9
Q

Possible genotypes

A1B

A

A1B

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10
Q

Possible genotypes

A2B

A

A2B

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11
Q

Possible genotypes

B

A

BB, BO

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12
Q

Possible genotypes

O

A

OO

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13
Q

Glycosyltransferase of H antigen

A

L-fucosyltransferase

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14
Q

Immunodominant sugar of H antigen

A

L-fucose

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15
Q

Glycosyltransferase of A antigen

A

N-acetylgalactosaminyltransferase

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16
Q

Immunodominant sugar of A antigen

A

N-acetyl-D-galactosamine

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17
Q

Glycosyltransferase of B antigen

A

D-galactosyltransferase

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18
Q

Immunodominant sugar of B antigen

A

D-galactose

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19
Q

Glycosyltransferase of AB antigen

A

N-acetylgalactosaminyltransferase
D-galactosyltransferase

20
Q

Immunodominant sugar of AB antigen

A

N-acetyl-D-galactosamine
D-galactose

21
Q

Comparison of Type 1 and Type 2 chains:

Linkage: Beta 1,3

A

Type 1

22
Q

Comparison of Type 1 and Type 2 chains:

Beta 1,4

A

Type 2

23
Q

Comparison of Type 1 and Type 2 chains:

Origin of Type 1

A

Plasma

24
Q

Comparison of Type 1 and Type 2 chains:

Origin of type 2

A

Synthesized on erythrocytic precursors

25
Q

Comparison of Type 1 and Type 2 chains:

controlling genes of Type 1

A

H, A, B, Se and Lewis

26
Q

Comparison of Type 1 and Type 2 chains:

Controlling genes of Type 2

A

H, A, B

27
Q

Subgroups of A:

A1

A

✅ Branched A antigens
✅ 2 million A antigen/adult red cells
✅ Positive with anti-A
✅ Positive with anti-A1 lectin

28
Q

Subgroups of A:

A2

A

✅Linear A antigens
✅500,000 A antigens/adult red cells
✅Positive with Anti-A
✅Negative with anti-A1 lectin

29
Q

Other subgroups of A:

Mixed field agglutination with anti-A and/or anti-AB

A

A3

30
Q

Other subgroups of A:

Weak agglutination with anti-AB only

A

Ax

31
Q

Other subgroups of A:

Less than or equal to 10% red cells show very weak mf agglutination

A

A end

32
Q

Other subgroups of A:

No agglutination with anti-A and anti-AB, secretors demonstrates quantities of A substance in saliva

A

Am

33
Q

Other subgroups of A:

No agglutination with anti-A and anti-AB, secretors contain small amount of A substance in saliva

A

Ay

34
Q

Other subgroups of A:

No agglutination with anti-A and anti-AB, secretors contain only H substance and no A substance in saliva

A

A el

35
Q

Subgroups of B:

mixed field agglutination with anti-B and/or anti-AB

A

B3

36
Q

Other subgroups of B:

Agglutination with anti-AB (wk/0 with anti-B)

A

Bx

37
Q

Other subgroups of B:

No agglutination with anti-B and anti-AB, secretors demonstrates quantities of B substance in saliva

A

Bm

38
Q

Other subgroups of B:

No agglutination with anti-B and anti-AB, secretors contain only H substance and no B substance in saliva

A

Bel

39
Q

Rare phenotypes in which the RBCs are completely devoid of H antigens or have small amounts of H antigen present

A

Para-bombay

40
Q

RBCs of these individuals express weak forms of A and B antigens, which are primarily detected by adsorption and elution studies

A

Para-Bombay

41
Q

If a person is genetically A or B, the respective enzymes can be detected, but no H enzyme is detectable, even though it has been shown that there is limited production of H antigen on the RBCs

A

Para-Bombay

42
Q

Required antigens:

📍 Reported in persons of Type O or B in association with severe infections caused by Proteus mirabilis
📍Tn-activated erythrocytes

A

Acquired A Antigen

43
Q

Required antigens:

📍Associated with conditions as carcinoma of the colon or rectum, intestinal obstruction, massive infection of lower gastrointestinal tract, and septicemia caused by Proteus vulgaris

A

Acquired B antigen

44
Q

Acquired antigens:

📍Can also result from increased permeability of the intestinal wall and subsequent absorption of bacterial polysaccharide (Escherichia coli O86) on the erythrocyte

A

Acquired B antigen

45
Q

Give the characteristics of the blood group:

A

A

✅IgM
✅Reacts at room temp
✅Naturally-occurring
✅Cannot cross the placenta

46
Q

Give the characteristics of the blood group:

B

A

✅IgM
✅Reacts at room temp
✅Naturally occurring
✅Cannot cross the placenta

47
Q

Give the characteristics of the blood group:

O

A

✅Predominantly IgG
✅Reacts at 37C
✅Immune antibody
✅Can cross the placenta

ISBB!!!! (24 decks)

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