BLOOD COMPONENTS AND DERIVATIVES Flashcards
Massive transfusion where both red cell mass and plasma volume are required
Whole blood
Replacement of the O2 carrying capacity and maintenance of the intravascular volume
Whole blood
Used in active brisk bleeding
Whole blood
A product in w/c all of the red cells & most of the plasma from the original unit remain
Whole blood
ml of whole blood
540 ml
Shelf life of whole blood
CPD – 21 days;
CPDA1 – 35 days at 1-6°C
Packed RBC with reduced plasma (avoid circulatory overload) volume
Red blood cells
Red blood cells may be prepared from whole blood by overnight
Sedimentation or by centrifugation using heavy spin
To increase O2 carrying capacity of blood in patients with acute/ chronic anemia
Red blood cells
ml of red blood cells
260 ml
Shelf life of red blood cells
CPD – 21 days;
CPDA1 – 35 days at 1-6°C
RBCs with reduced plasma volume and an additional of 100 mL additive solution
RED BLOOD CELLS IN ADDITIVE SOLUTION (ADENINE-SALINE)
mL of RED BLOOD CELLS IN ADDITIVE SOLUTION (ADENINE-SALINE)
340 ml
Shelf life of RED BLOOD CELLS IN ADDITIVE SOLUTION (ADENINE-SALINE)
42 days at 1-6°C
Prevention of recurrent or severe allergic reactions
WASHED RBCS ( NO PLASMA )
WASHED RBCS ( NO PLASMA ) is used for what transfusion
Neonatal intrauterine transfusion
Prevention of anaphylactic reactions in IgA-deficient patients
WASHED RBCS ( NO PLASMA )
Shelf life of WASHED RBCS ( NO PLASMA )
24 hours at 1-6°C
Removes >90% of WBC
No plasma
FROZEN DEGLYCEROLIZED RBCS
Long-term preservation of RBC units with rare phenotype or autologous RBC units
FROZEN DEGLYCEROLIZED RBCS
Alternative to CMV-seronegative units in
emergencies
FROZEN DEGLYCEROLIZED RBCS
Decreases febrile transfusion reactions
FROZEN DEGLYCEROLIZED RBCS
mL of FROZEN DEGLYCEROLIZED RBCS
250 mL
Shelf life of FROZEN DEGLYCEROLIZED RBCS
10 years at -65°C to -200°C
24 hours at 1-6°C after washing (AG:40% glycerol)
Decreases risk of alloimmunization to HLA antigens on leukocytes
LEUKOCYTE-REDUCED RBCS
Decrease febrile non-hemolytic transfusion reactions
LEUKOCYTE-REDUCED RBCS
Reduce the risk of CMV infection
LEUKOCYTE-REDUCED RBCS
Decrease immunomodulation, and may decrease the risk of prion transmission in B lymphocytes
LEUKOCYTE-REDUCED RBCS
3 log filtration
LEUKOCYTE-REDUCED RBCS
Two RBC is divided into two separate RBC units of equal volume
TWO-UNIT RBCS, APHERESIS
Similar to pRBC (increase oxygen carrying capacity)
TWO-UNIT RBCS, APHERESIS
Volume of TWO-UNIT RBCS, APHERESIS
320 ml
Shelf life of TWO-UNIT RBCS, APHERESIS
1 year at 1-6 °C
Bleeding due to quantitative and qualitative platelet disorders
RANDOM DONOR PLATELET CONCENTRATE
Prophylaxis in severely thrombocytopenic patients (5,000 – 10,000/uL)
RANDOM DONOR PLATELET CONCENTRATE
Volume of RANDOM DONOR PLATELET CONCENTRATE
50 - 70 mL
Shelf life of RANDOM DONOR PLATELET CONCENTRATE
5 days at 20-24 °C with constant gentle agitation & 4 hours after pooling
Platelets in approx. 250ml of plasma to maintain pH above 6.2
▪ Indications, similar to random donor platelets
PLATELETS, PHERESIS (SINGLE DONOR PLATELETS)
Volume of PLATELETS, PHERESIS (SINGLE DONOR PLATELETS)
200 - 400 ml
Shelf life of PLATELETS, PHERESIS (SINGLE DONOR PLATELETS)
5 days at 20-24°C with constant gentle agitation
3rd gen filter
LEUKOCYTE REDUCED PLATELETS
Bedside filtration is done immediately before transfusion (3log filters)
LEUKOCYTE REDUCED PLATELETS
