Maeve Onc Flashcards
Primary malignancy most likely to get second malignant neoplasm?
Order of likelihood:
- Hereditary retinoblastoma (not sporadic!)
- Hodgkin
- Soft tissue sarcoma
Which phase of cell cycle - bleomycin
G2
Which phase of cell cycle - cytatabine
S phase
Which phase of cell cycle - asparaginase
G1
Primary bladder malignancy is uncommon in children except for
Rhabdomyosarcoma
Small round blue cell
5 yo boy on chemo for ALL w low grade fevers + behavioural changes. CSF stained w india ink shows cells with a halo surrounding them. Whats the organism?
Cryptococcus neoformans
Chemo most likely to cause:
Low phosphate
Low bicarb
Glucose + protein in urine
Isofosfamide
Testicular relapse in the first 2 years following initial diagnosis is most likely to occur in patients w what?
T-lineage acute lymphoblastic l (ALL)
Occurs in 1-2% of boys w ALL - painless swelling of both testes
Reed sternberg cells
Hodgkin lymphoma
Steroid SEs
Immunosupression, weight gain, weakness, mood swings, stomach ulcers, elevated BP, sleep issues, high BGL, avascular necrosis, bone demineralisation/ OP
Jaw + bone pain + constipation. Which chemo?
Vincristine
MMF SEs
GI - abdo pain, anorexia, constipation/ diarrhoea, GI haemorrhage, N+V
What mutation correlates with good prognosis in medulloblastoma?
Wnt mutations
3 Things to prevent toxicity duting MTX therapy
Folinic acud
Urinary alkalisation
Hyperhydration
FUH
Auer rod =
AML
