Cardiology Flashcards
S1 is associated with closure of which valves?
Mitral and tricuspid
Wide splitting of S1 is associated with which conditions?
RBBB and Ebstein’s Anomaly
In inspiration there is increased systemic venous return to the heart and thus there is delayed closure of ______ valve
Pulmonary valve; delayed P2 sound
Widely split S2 occurs in conditions with prolonged _____ ventricular ejection time; Which conditions do you see this in?
ASD, PAPVR, Pulmonary stenosis, RBBB
You may also see wide S2 split in conditions with shortened LV ejection in conditions like ____
MR
Narrowly split S2 occurs when ____ valve closes early. It is associated with _______.
It may also be seen in conditions where _____ valve closure is delayed like _____.
Pulmonary valve closes early and associated with pulmonary hypertension.
It may also be seen when AV closure is delayed in conditions like Aortic Stenosis
Single S2 can occur when there is only one semilunar valve (i.e. conditions like _____ or ______ or _______); or when P2 is not audible (i.e. ____ or ____ or _______) or when P2 is early (in pulmonary hypertension)
Single S2 when only one semilunar valve is present (aortic or pulmonary atresia or truncus arteriosus); when P2 not audible (TGA, TOF, severe PS), when aortic closure is delayed (severe AS), or P2 is early (pulm htn)
Paradoxical split is when aortic closure follows pulmonary closure and LV ejection is greatly delayed. In which conditions is this seen?
Severe AS, WPW, LBBB
There is increased intensity of P2 with which condition?
Pulmonary hypertension
S3 is a low frequency sound heard in early diastole. This is related to ____________.
It can be normal but can also be associated if ventricular compliance is decreased in conditions like __________.
S3 is due to rapid ventricular filling, hear at apex or LL sternum.
This may be normal, but can be associated in conditions with dilated ventricles - Large VSD, CCF
S4 is a sound in late diastole. Is it always pathological?
Always pathological and associated with decreased ventricular compliance
Boot shaped heart is associated with which condition?
TOF
Paracrine regulation of blood flow:
- Vasodilatation is due to ______, _______ and _______
- Vasoconstriction is due to _______
Vasodilatation is due to Nitric oxide, bradykinin and prostacyclin.
Vasoconstriction is due to endothelin-1.
Name 5 extrinsic factors/regulators which cause increase vasoconstriction/vascular resistance?
Alpha-adrenergic sympathetic nerves, Angiotensin II, ADH (Vasopressin), Prostaglandin H2, Thromboxane (released by platelets due to decrease blood flow to injured vessels)
Name 4 extrinsic regulators of Vasodilatation?
Cholinergic sympathetic response, Parasympathetic NS, Histamine (localised vasodilatation in inflammation and allergic reactions), Prostaglandin I2
Increased Co2 or decreasedO2 causes ______ of cerebral blood vessels with aim to ______
Dilatation of cerebral blood vessels with aim to increase cerebral blood flow
4 common ECG changes seen with hypothyroidism?
Sinus bradycardia
Long QT interval
Flat or inverted T waves
Low voltage QRS complexes
3 common ECG changes with hyperthyroidism?
Sinus tachycardia
Increased QRS voltages
Atrial fibrillation
J waves on an ECG are seen in ______
Takotsubo cardiomyopathy
Hypercalcaemia
Hypothermia
A short QT interval is seen with hyper or hypothermia?
Hyperthermia
ECG features in hypocalcaemia?
Long ST segment, Long QTc interval
Prominent U waves are seen with?
Hypokalaemia
In Mitral Regurgitation you get a pansystolic murmur with an additional ___________ murmur in severe MR.
You get development of a mid diastolic rumble; this occurs because of increased blood flow over the thickened mitral valve.
AKA Carey Coombs murmur
In Atrial regurgitation you get _________ murmur
HDM +/‐ Austin flint
murmur
What are the ECG findings in Brugada syndrome?
Patients have ECG findings of ‘coved’ ST elevation in V1/V2 and pseudo-RBBB. Tachy-arrhythmias may be triggered by fever.
What are the most common CHD seen in William’s Syndrome?
Supravalvular aortic stenosis (75%)
Peripheral pulmonary stenosis (40%)
Supravalvular pulmonary stenosis (20%)
Coarctation of the aorta 2-70%
Beware of coronaries 5-10% risk of sudden death
and also screen for Renal arteries
What are the most common CHD seen in Noonan syndrome?
Pulmonary stenosis (dysplastic pulmonary valve) - 50% HOCM 20%
What are the most common CHD seen in Alagille syndrome?
Branch/peripheral pulmonary stenosis - 70%
Tetrology of fallot - 10%
ASD/VSD
Aortic stenosis
Differences in situs inversus vs situs ambiguous?
Situs inversus - everything flipped
Situs ambiguous - intermediate configuration of thoracic and abdominal viscera = heterotaxy syndrome
In situs inversus - 3-5% have CHD with most common association between ______.
20% have ________ syndrome
Associated with L-TGA
20% have associated Kartageners syndrome
Left atrial isomerism is associated with 4 common things….
Polysplenia - multiple small spleen (non-functioning)
Central transverse liver
Interrupted IVC (azygous/hemi-azygous continuation)
CHD - less common (50%) and simple acyanotic
Right atrial isomerism is associated with 4 common things…
- Asplenia
- Central/transverse liver
- Bilateral right atria and right lungs
- CHD - very common (90%) and complex cyanotic + anomalous pulmonary venous return
Blue Trisomy 21 = ______
tetrology of fallot
Turner’s syndrome = _______
Left heart lesions (bicuspid aortic valve)
William’s syndrome = ___________
Supravalvular problems (AS/PS/Peripheral PS)
Stretched marfan = _______________
Stretched aorta and/or mitral valve
Noonan syndrome associated with _____ axis
Superior axis
50% of kids with interrupted arch have _____
22q11 deletion syndrome
In WPW, _____ or ________ may increase rate of anterograde conduction and should be avoided.
Avoid Digoxin and CCB
What medication is used for SVT refractory to Adenosine in a haemodynamically stable patient?
Amiodarone
What is the medication of choice in a stable patient with VF or VT?
Stable patient, IV procainamide, sotalol, or amiodarone is acceptable. Amiodarone is preferred in patients with impaired left ventricular function or in patients with heart failure.
What is the treatment of choice for multifocal atrial tachycardia?
Sotalol
Name 4 common findings with hypokalaemia?
Prolongation of QT interval
ST-segment depression
T-wave flattening
Appearance of U waves
__________- closes from top to bottom on the right side of the heart;
Foramen ovale is created by a gap in the __________.
(ASD related)
Septum primum closes from top to bottom;
Foramen ovale is created by a gap in the septum secundum.
Most ASD cases are due to _________; failed closure
Ostium secundum
What ASD defects are most commonly seen in down syndrome?
Defects due to Ostium Prmum and thus relates to AVSD
Sinus venosus ASD are almost always associated with ……
Partial anomalous right sided pulmonary venous drainage
Most common type of VSD?
Perimembranous VSD (80%)
Inlet VSD associated with _____
AVSD
AVSD is typically a combination of….
Primum ASD and inlet VSD
if only one of the above, then partial AVSD
Once AVSD repaired complications can be ?
AV valve regurgitation