Lysozyme Flashcards
1
Q
Who discovered lysozyme?
A
Alexander Fleming in the 1920s
2
Q
Where are lysozymes found?
A
Tears and mucus
3
Q
What family are lysozymes a member of?
A
GH22
4
Q
What bonds do lysozymes cleave?
A
The β-1,4 linked N-acetyl-muramic-acid (MAM) and N-acetyl-glucosamine (NAG) of peptidoglycan in bacterial cell walls
5
Q
What types of enzymes are lysozymes?
A
Endo acting and retaining
6
Q
How is deglycosylation slowed down?
A
Glutamate is mutated into glutamine
Fluorine is added at the C2 to slow down the formation of the transition state
