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Hugh's MD2 Pathology > Lymphoid Tissue > Flashcards

Lymphoid Tissue Flashcards

1
Q

What are the causes of lymphadenopathy?

A

Reactive

  • infection or non-infective

Malignant

  • Lymphoma or metastasis
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2
Q

In which malignancies can granulomas be seen?

A

Carcinoma

Seminoma

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3
Q

What is the histopathological pattern of melanoma in a LN?

A

Large single cells with lots of cytoplasm

+/- pigment

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4
Q

What is the histopathological feature of sarcoma?

A

Spindle cells

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5
Q

What non-infective and non-malignant causes of reactive lymphadenopathy?

A

Sarcoid

RA

SLE

Drug induced

Foreign body

Perimalignant (adjacent to a tumour)

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6
Q

What do you see in the LNs in a bacterial infection?

A

Neutrophils

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7
Q

What do you see in the LNs in a parasitic infection?

A

Eosinophils

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8
Q

What do you see in the LNs in TB?

A

Caseating granulomatous tissue

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9
Q

Where does Hodgkin lymphoma typically present?

A

Neck and mediastinal nodes

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10
Q

Which type of lymphoma is common in the groin?

A

T-cell lymphoma

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11
Q

A polyclonal process is typical of benign or malignant lymphoma?

A

Benign

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12
Q

A monoclonal process is typical of benign or malignant lymphoma?

A

Malignant

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13
Q

Which lymphoma has a classic starry sky appearance on histopath?

A

Burkitt lymphoma

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14
Q

How do nodes in Hodgkin lymphoma feel on palpation?

A

Rock hard

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15
Q

How do plasma cell typically appear?

A

Eccentric round nuclei

Clumped, clock-face nuclei

Perinuclear hoff

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16
Q

What is plasmacytoma?

A

Usually solitary, bone marrow not involved

17
Q

What is the kappa/lambda pattern in multiple myeloma?

A

Cells only express one of the two

18
Q

What is the name of the light chain protein filtered in the kidney in MM?

A

Bence Jones proteins

19
Q

What are the renal manifestations of MM?

A

Hypercalcaemia > renal stones

Cast nephropathy (with Bence Jones proteins)

Neoplastic infiltration

Amyloidosis

20
Q

What is the pathophysiology of amyloidosis?

A

Deposition of misfolded beta-sheets protein into various tissues of the body

21
Q

What is the difference between primary and secondary amyloidosis?

A

Primary - usually associated with plasma cell or lymphoplasmocytic lesions

Secondary - associated with other chronic disease eg TB, RA

22
Q

Where does endocrine amyloidosis manifest?

A

Thyroid

Islets of Langerhans in pancrease

23
Q

How is the diagnosis of amyloidosis made?

A

Biopsy of organ with amyloid congo red stain positive

Hugh's MD2 Pathology (17 decks)

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