Hepatobiliary Pathology Flashcards
What is cirrhosis?
Bands of fibrosis that surround nodules that is diffuse and distorts the normal structure of the liver
What is pathophysiology of primary biliary cirrhosis?
Non-suppurative autoimmune attack of the small bile ducts in the liver with underlap onto hepatocytes causing eventual cirrhosis to occur
What is the pathophysiology of primary sclerosing cholangitis?
Autoimmune attack of large extra and intrahepatic bile ducts causing irregular stenosis and strictures of the bile duct
What are the three big causes of hepatitis?
Viral
Autoimmune
Drug induced
What is the pathological difference in acute vs chronic viral hepatitis?
Acute - Lobular inflammation/disarray
Chronic - Periportal inflammation
What is the risk of cirrhosis in Hep C chronic infection?
25%
Which Hep virus increases the risk of hepatoma and cirrhosis greater respectively?
Hepatoma: Hep B
Cirrhosis: Hep C
What diseases predispose people to developing primary sclerosing cholangitis?
IBD
Which goes off first in liver failure, INR or albumin?
INR
What does an elevated ANA indicate in the liver setting?
Primary biliary sclerosis
What Ix finding are present in PBC?
Elevated GGT and ALP
Elevated IgM
Mnti-mitochondrial ab’s type M2
How elevated are the transanimases in chronic hep C?
60-300
What is the function of bile?
Emulsify fat
Excrete bilirubin breakdown products
