CNS Pathology Flashcards
What is a Pittsburgh B scan for?
Lights up amyloid protein in investigation of AD
What are MRI finding in brain atropy?
Enlarged ventricles
Reduced size of gyri
Increased relative size of sulci
What is amyloid?
Insoluble protein deposited in extracellular space that has a tightly folded beta-pleated structure
What stains are specific for amyloid?
Congo red (formalin)
Thioflavin T stains (frozen sections)
What are some histopath feature of GBM?
Hypercellularity with mitoses
Nuclear processes
No defined cellular membrane
Endothelial cell hyperplasia
What does the presence of a IDH-1 mutation in a GBM predict?
Better response to chemotherapy - temozolamide
How do meningomas appear histopathologically?
Whirl bodies
How do pituitary adenoma present?
Headache
Visual changes
Acromegaly
Cushing’s
Hyperprolactinaemia
Which
Lung
Breast
Melanoma
Renal cell cancer
Colonic
When are brain abscess seen?
First 4 decades of life
What is the etiology of brain abscesses?
Direct extension
Haematological spread
Trauma
Unknown
What are the major pathiological findings in PD?
Loss of pigmentation in the substantia nigra
Lewy bodies and lewy neurites
What is primary angiitis?
Rare disorder of CNS
Vasculitis of the CNS only
