Endocrine Pathology Flashcards
DDx for neck lumps?
Thyroid lesions
Lymph node
Cyst
Abscess
Parathyroid lesion
Malignancy
What is the name of the extra thyroid tissue that extends superiorly?
Pyramidal node
DDx for thyroid lumps?
Diffuse goitre
Solitary thyroid nodule
- Benign/Malignant
Do you do an FNA or core biopsy for thyroid lumps?
FNA - due to bleeding risk
How do multi-nodular goitres appear on histology?
Irregular sized follicles
Scar tissue
What are the benign thyroid lumps?
Colloid nodule
Follicular adenoma
How does a follicular adenoma appear on histology?
Capsule with microfollicles
What is the histological appear of papillary carcinoma?
Soft, friable
Non-clearly demarcated capsule
Papillary projections
Large, optical clearing of chromatin and nuclear groove in nucleus
Microcalcification - psammoma bodies
What is the most common malignant thyroid nodule?
Papillary carcinoma
How do you tell the difference between a follicular carcinoma from a follicular adenoma?
Larger
Thicker capsule
Capsular invasion
Vascularisation
How does medullary carcinoma appear histologically?
No follicles
Amyloid deposition
How do anaplastic carcinomas appear?
High grade, undifferentiated tumour cells
