Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

IMMUNOLOGY & SEROLOGY (TopnotcherQT) > LYMPHOID SYSTEM > Flashcards

LYMPHOID SYSTEM Flashcards

memorization

1
Q

Primary lymphoid organs

A
  1. Bone marrow
  2. Thymus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Source of progenitor cells (hematopoiesis); site of B cell maturation

A

Bone marrow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Site of T-cell maturation:

A

Thymus

Note: Progenitor cells that migrate to the thymus proliferate and differentiate under the influence of thymosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Secondary lymphoid organs:

A
  1. Lymph nodes
  2. Spleen
  3. MALT
  4. Cutaneous immune system (epidermis, dermis)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Secondary lymphoid organ that traps subcutaneous antigens:

A

Lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Secondary lymphoid organ that is made up of red and white pulp where most lymphoid tissue is located; traps intravenous antigens:

A

Spleen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which part of the lymph nodes does B-cells proliferate?

A

Cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which part of the lymph nods does T-cells proliferate?

A

Paracortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Macrophages proliferate in the _____ part of the lymph nodes

A

medullary/medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Only mature WBC that can still undergo mitosis (clonal expansion):

A

Lymphocyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What part of the spleen does T-cells proliferate?

A

Periarterial lymphatic sheath (PALS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What part of the spleen does B-cells proliferate?

A

Follicular area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What part of the spleen does macrophages proliferate?

A

Marginal zone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MALT stands for:

A

mucosa-associated lymphoid tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Examples of MALT:

A

Peyer’s patches - small intestines
Tonsils
Appendix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

A type of dendritic cell that is present in the epidermis:

A

Langerhans cells - a special class of APC and a type of dendritic cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Products produced by B cells:

A

Antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Products produced by T cells:

A

Cytokines/lymphokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

CD markers present in B cells:

A

CD 19
CD 20
CD 21
CD 40

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

CD marker of B cell that functions as PANMAKER:

A

CD 19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

CD marker of B cell that functions as ion channels:

A

CD 20

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

CD marker of B cell that functions as C3d receptor:

A

CD 21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

CD marker of B cell that functions as the receptor of Epstein-Barre Virus (EBV):

A

CD 21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

CD marker of B cell that functions as B cell isotype switching and memory formation

A

CD 40

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
CD markers present in T cells:
CD 2 CD 3 CD 4 CD 7 CD 8
26
Classic T-cell marker, sheep RBC receptor:
CD 2
27
CD marker part of the TCR complex:
CD 3
28
Coreceptor of MHC class II:
CD 4
29
Coreceptor of MHC class I:
CD 8
30
Identification method for B cells:
Surface immunoglobulins
31
Identification method for T cells:
Rosette formation with sheep RBC
32
A technique to separate lymphocytes from whole blood:
FICOLL-HYPAQUE CENTRIFUGATION
33
Ficoll-Hypaque has a specific gravity between:
1.077 - 1.114
34
What type of blood specimen should be utilized in Ficoll-Hypaque centrifugation?
Diluted defibrinated or heparinized blood or ACD blood
35
The gold standard test for the identification of lymphocytes
FLOW CYTOMETRY with light scatter - It is coupled with the detection of surface markers (proteins) using FLUORESCENT LABELED ANTIBODIES
36
T cell antigens (CD markers) detected by immunofluorescence:
CD 2 CD 3 CD 4 CD 7 CD 8
37
B cell antigens (CD markers) detected by immunofluorescence:
CD 19 CD 20 CD 22
38
Cheapest manual lymphocyte identification technique:
Rosette techniques (E-rosette assay) (Erythrocyte-Ab-Complement Rosette)
39
E-rosette assay test mechanism:
Sheep cells attach to the CD2 antigen, found only on T cells
40
The Erythrocyte-Ab-Complement technique is a manual lymphocyte technique for the identification of:
B cells Note: B cells have C3 receptor which is why it involves the use of antibodies and complement
41
T lymphocytes represent approximately ____% of the circulating lymphocytes in the peripheral blood.
80%
42
Surface marker of subtype Tc
CD 8
43
Function of subtype Tc
Destroys virally infected and tumor cells through secretion of perforins and granzymes
44
Surface marker of subtype Th
CD 4
45
Th subset that helps B cell to become a Plasma cell:
Th 2
46
Th subset that enhances the activity of cytotoxic cells and activates macrophages:
Th 1
47
Surface marker of subtype Ts:
CD 8
48
Function of subtype Ts:
Limit immune reactions
49
Surface marker of subtype Tm:
CD8 & CD4
50
Function of subtype Tm:
Circulate in immunosurveillance and anamnestic response
51
These are substances that promote cell division:
Mitogens
52
Enumerate T cell mitogens:
- Concanavillin A - Phytohemagglutinin - Pokeweed mitogen
53
Enumerate B cell mitogens:
- Lipopolysaccharide - Pokeweed mitogen
54
Helper T (Th) cells approximately represents _____% of lymphocytes in the blood:
50-60%
55
Cytotoxic T (Tc) cells approximately represents ______% of lymphocytes in the blood
20-25%
56
Natural Killer cells approximately represents ____% of lymphocytes in the blood
~ 10%
57
B cells approximately represents _____% of lymphocytes in the blood
10-15%
58
Normal CD4 count:
500 - 1200/uL
59
CD4+ cells to CD8+ cells ratio:
2:1
60
Ratio of CD4+ cells to CD8+ cells in HIV:
1:2 to 0.5:1
61
CD4+ cell count in AIDS:
<200/uL
62
In the cortex of the thymus, immature T cells represent _____%
85%
63
In the medulla of the thymus, mature T cells represent ____%
15%
64
(Maturation of T lymphocytes in the thymus) Expression of the classical T-cell marker; Early thymocytes lack CD4 and CD8 markers, which are important to their later function; hence, they are known as:
Double Negative (DN) thymocytes
65
(Maturation of T lymphocytes in the thymus) Expression of both CD4 and CD, making them:
Double Positive (DP) thymocytes
66
Presence of CD 19 and CD45R; Rearrange of genes coding for heavy chains at chromosome 14:
Pro-B cell
67
Synthesize IgM heavy chains (u chains) confined to the cytoplasm; Light chain gene rearrangement:
Pre-B cell
68
kappa = chromosome ___ lambda = chromosome ___
kappa = chromosome 2 lambda = chromosome 22
69
Decreased cytoplasmic IgM; surface IgM present on the cell surface; CD 19, 20, and 21 positive
Naive B cell
70
Presence of surface IgM and IgD
Mature B cell
71
Antibody producing cells, derived from B cells which are exposed to various ILs and antigenic stimulation:
Plasma cell

IMMUNOLOGY & SEROLOGY (TopnotcherQT) (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions