ANTIGEN PRESENTATION Flashcards
memorization
MHC I of virally infected cell is recognized by:
T cytotoxic cell (CD8+)
Tc is activated by ______ produced by the _____
Tc is activated by IL-2 produced by Th (T helper cell)
Activated Tc kills virally infected cells through:
- PERFORINS
- GRANZYMES
In class II MHC presentation, APC produces ______ to stimulate Th cell to produce _____ which activates the ________
APC produces IL-1 to stimulate the Th cell to produce IL-2 which activates the Th cell (autoactivating)
- APC presents antigenic fragments through ______
- _____ recognizes MHC II
- Th cells produces _____ and becomes activated
- APC presents antigenic fragments through MHC II
- Th cells recognize MHC II
- Th cells produces IL-2 and becomes activated
____ stimulates activated Th cell to become Th 1
IL-12 stimulates activated Th cell to become Th 1
____ stimulates activated Th cell to become Th 2
IL-4 stimulates activated Th cell to become Th 2
Th1 cells produce ________ which activates phagocytes to kill ingested microbes
IFN-y
Note: IFN-y stimulates the production of antibodies that promote the ingestion of microbes by the phagocytes; production of op
Th1 mediates type _____ HSR and also mediates _______ immunity.
Th1 mediates type IV HSR and also mediates cellular immunity
Th2 cells produce ______, which stimulates the production of _______, and ______.
Th2 cells produce IL-4, which stimulates the production of IgE, and IL-5
IL-4 also stimulates the production of a neutralizing IgG antibody called _____
IgG4
Note:
IgG4 - neutralizing Ab; has the capability to bind the receptors of the viruses/bacteria so that these pathogens cannot bind to the normal host cells.
IL-5 activates ________
Eosinophils
IgE activates _______ and coats ________ for destruction by eosinophils:
IgE activates mast cells and coats helminths for destruction by eosinophils.
Th2 mediates type ___ HSR and also mediates _______ immunity
Th2 mediates type 1 HSR and also mediates humoral immunity
