Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

RUSVM Immunology > Lymphocytes > Flashcards

Lymphocytes Flashcards

1
Q

Lymphocytes can be broken down into 3 families _________, __________ and __________.

A

Lymphocytes can be broken down into 3 families NK cells, T cells and B cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

NK cells are apart of the __________ response.

A

NK cells are apart of the innate immune response.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

T cells are part of the ________ response.

A

T cells are part of the cellular immune response.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Function of the helper T cells is to _____________.

A

Function of the helper T cells is to regulate immune response.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Subpopulations of helper T cells include _______, ______ and __________.

A

Subpopulations of helper T cells include Th1, Th2 and Th17.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cytotoxic T cells destroy cells expressing __________ antigens.

A

Cytotoxic T cells destroy cells expressing endogenous antigens.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Function of the T regulatory cells is to ________________.

A

Function of the T regulatory cells is to control everything.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

B cells are a part of the __________ response and produce _________.

A

B cells are a part of the humoral immune response and produce antibodies.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Subpopulations of B cells include _________ and ___________.

A

Subpopulations of B cells include Memory B Cells and Plasma Cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

CD4 activates __________ and are receptors for MHC class _______ molecules.

A

CD4 activates helper T cells and are receptors for MHC class II molecules.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CD8 activates __________ and is the receptor for MCH class _________ molecules.

A

CD8 activates cytotoxic T cells and is the receptor for MCH class I molecules.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The major molecules expressed on the surface of T lymphocytes are ________, ___________, _________ and __________.

A

The major molecules expressed on the surface of T lymphocytes are T cell antigen receptors (TCR), surface antigens, T cell receptors and mitogens.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Important T cell antigen receptors include ________ and ___________.

A

Important T cell antigen receptors include TCR alpha/beta and TCR gamma/delta.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Important surface antigens of T cells include ___________________.

A

Important surface antigens of T cells include CD2, CD3, CD4 and CD8.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Important T cell receptors include _________, __________ and _________.

A

Important T cell receptors include regulatory receptors, antigen-receptor complex and transport receptor.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Regulatory receptor, H3 is a receptor for _______________.

A

Regulatory receptor, H3 is a receptor for histamine.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Regulatory receptor, CD25 is a receptor for _______________.

A

Regulatory receptor, CD25 is a receptor for IL-2.​

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Regulatory receptor, CD2 is a receptor for _______________.​

A

Regulatory receptor, CD2 is a receptor for CD58.​

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Regulatory receptor, CD35 (C3b, C4b) is a receptor for _______________.​

A

Regulatory receptor, CD35 (C3b, C4b) is a receptor for complement.​

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Regulatory receptor, FcR is a receptor for _______________.​

A

Regulatory receptor, FcR is a receptor for immunoglobulins.​

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Antigen receptor complex, CD3 plays a crucial role in ____________.

A

Antigen receptor complex, CD3 plays a crucial role in TCR complex.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Antigen receptor complex, CD4/CD8 is a receptor for ____________.

A

Antigen receptor complex, CD4/CD8 is a receptor for MHC molecules.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

CD71 is a receptor for __________.

A

CD71 is a receptor for transferring.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Mitogens for T cells are _________, ___________, ___________ and _________.

A

Mitogens for T cells are phytohemagglutinin, concanacalin A, BCG vaccine and pokeweed.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Major molecules expressed on the surface of B lymphocytes are _____________, ___________, ___________ and ___________.

A

Major molecules expressed on the surface of B lymphocytes are Bcell antigen receptors, surface antigens, B cell receptors and mitogens.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

B cell antigen receptor binding chains are:

A

B cell antigen receptor binding chains are: BCR alpha, gamma, mew, epsilon, and delta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

___________ are important surface antigens of B cells.

A

Immunoglobulins are important surface antigens of B cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

_________, _________, _________ and ______________ are important B cell receptors.

A

Immunoglobulin receptors, antigen receptors, complement receptors and cytokine receptors are important B cell receptors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Immunoglobulin receptor, FcuR is a receptor for _________.

A

Immunoglobulin receptor, FcuR is a receptor for IgM.

30
Q

Immunoglobulin receptor, CD32 is a receptor for _________.

A

Immunoglobulin receptor, CD32 is a receptor for IgG.​

31
Q

CD21 (iC3b) is a _________ receptor for B cells.

A

CD21 (iC3b) is a complement receptor for B cells.

32
Q

CD35 (C3b, C4b) is a _________ receptor for B cells.

A

CD35 (C3b, C4b) is a complement receptor for B cells.

33
Q

CD25/CD122 is a cytokine receptor used for _________.

A

CD25/CD122 is a cytokine receptor used for IL-2.

34
Q

CD124 is a cytokine receptor used for _________.

A

CD124 is a cytokine receptor used for IL-4.​

35
Q

CD125 is a cytokine receptor used for _________.​

A

CD125 is a cytokine receptor used for IL-5.​

36
Q

_______ and _______ are B cell mitogens.

A

Pokeweed and lipopolysaccharide are B cell mitogens.

37
Q

Four componentss of the TCR

A
  1. Cytoplasmic Domain
  2. Transmembrane Domain
  3. Constant Domain
  4. Variable Domain
38
Q

Cytoplasmic domain

A

Portion of the receptor that extends into the cytoplasmic sapce of the T cell

39
Q

Transmembrane Domain

A

Portion of the receptor that is rooted into the membrane

40
Q

Constant Domain

A

portion of the receptor that remains constant (sequence of amino acids is constant)

41
Q

_____________is key in recognizing specific antigens.

A

**Constant Domain **is key in recognizing specific antigens.

42
Q

Constant domain is a bridge that holds the __________ and __________ together.

A

Constant domain is a bridge that holds the alpha and beta chains together.

43
Q

Variable Domain

A

Changes depending on the maturation of the T cell

44
Q

Predominant receptor for immune responses is _______________.

A

Predominant receptor for immune responses is TCR alpha/beta.

45
Q

The alpha chain of TCR alpha/beta is resposible for _______________.

A

The alpha chain of TCR alpha/beta is resposible for recognition of antigen and MHC.

46
Q

____________ plays a minor role in immune response, its function is not completely understood.

A

TCR gamma/delta plays a minor role in immune response, its function is not completely understood.

47
Q

Gamma chain of the TCR gamma/delta is responsible for ____________.

A

Gamma chain of the TCR gamma/delta is responsible for recognition of the antigen.

48
Q

TCR _______ participates in both innate and adaptive immune response.

A

TCR gamma/delta participates in both innate and adaptive immune response.

49
Q

TCR gamma/delta is found in the _____________ of the innate immune response.

A

TCR gamma/delta are found in the skin and uterus of the innate immune response.

50
Q

TCR gamma/delta of the adaptive immune response is found in ______________.

A

TCR gamma/delta of the adaptive immune response is found in GI tract and secondary lymphoid organs.

51
Q

TCR gamm/delta of the innate immunity produce ________ and ________.

A

TCR gamm/delta of the innate immunity produce IFN-gamma and IL-17.

52
Q

Th1 subset ________.

A

Th1 subset IFN-gamma.

53
Q

Th2 subset _________.

A

Th2 subset IL-4.

54
Q

Function of the CD3 complex is to ______________.

A

Function of the CD3 complex is to help activate the T cell.

55
Q

T cell receptors are essential for ______________.

A

T cell receptors are essential for recognition of antigens.

56
Q

__________ recognizes its respective MHC molecule.→ _____________ attaches and fits to antigen. → ___________ is triggered to send signals to the rest of the cell. → Cascade of immune response begins.

A

CD4/CD8 recognizes its respective MHC molecule.→ T cell receptor attaches and fits to antigen. → CD3 is triggered to send signals to the rest of the cell. → Cascade of immune response begins.

57
Q

TCR and CD4/CD8 have recognized an MHC and antigen, CD3 complex is triggered and what bonds are created?

A
  1. CD4 on APC binds to CD154
  2. CD80 (APC) or CD86 (B cell) bind to CD28 on T Cell
  3. CD80/86 binds to CD152 on T cell
58
Q

Binding of CD40 on the APC to CD154 triggers the APC to release __________.

A

Binding of CD40 on the APC to CD154 triggers the APC to release IL-1, IL-6, IL-8, IL-12, TNF-alpha, CCL3.

59
Q

CD80 on the APC or CD86 on the B cell bind to CD28 on the T cell to ____________.

A

CD80 on the APC or CD86 on the B cell bind to CD28 on the T cell to activate the T cell.

60
Q

T cells activated by the CD80/CD86 bound to CD28 stimulate the production of _________.

A

T cells activated by the CD80/CD86 bound to CD28 stimulate the production of IL-2.

61
Q

IL-2 upregulates ___________, increases ________ and promotes ______ division.

A

IL-2 upregulates cell survival genes, increases energy metabolism and promotes T cell division division.

62
Q

CD80/CD86 also binds to CD152 on the T cell causing _____________.

A

CD80/CD86 also binds to CD152 on the T cell causing inactivation of T cell.

63
Q

T cell suppression mechanism:

Production of _____________ → destroy _________ → absence makes T cell __________ to antigen → T cell response is terminated

A

T cell suppression mechanism:

Production of indoleamine dioxygenase → destroy Tryptophan → absence makes T cell unresponsive to antigen → T cell response is terminated

64
Q

__________ plays a significant role in amplifying the signal that is produced after an antigen is recognized.

A

Co-stimulation plays a significant role in amplifying the signal that is produced after an antigen is recognized.

65
Q

Immunoglobulin superfamily includes _____, _________ and ________.

A

Immunoglobulin superfamily includes TCR, **MHC molecules **and BCR.

66
Q

All the receptors are in the superfamily of immunoglobulin because they all have ______________.

A

All the receptors are in the superfamily of immunoglobulin because they all have similar structures.

67
Q

CD4+ T cells are found on _________.

A

CD4+ T cells are found on helper T cells.

68
Q

Elevated levels of _______ suggest increased lymphocyte reactivity.

A

Elevated levels of CD4+ suggest increased lymphocyte reactivity.

69
Q

CD8+ T cells are found on ___________.

A

CD8+ T cells are found on cytotoxic T cells.

70
Q

Elevated levels of _____suggest depressed lymphocyte reactivity.

A

Elevated levels of **CD8+ **suggest depressed lymphocyte reactivity.

71
Q

CD4 or CD8 are not expressed on _______ or ________.

A

CD4 or CD8 are not expressed on B cells or NK cells.

RUSVM Immunology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions