Immunodeficiency Flashcards
As a result of genetic mutations, defects develop in the developing immune system resulting in ________ in new-born animals.
As a result of genetic mutations, defects develop in the developing immune system resulting in immunodeficiency in new-born animals.
Defects in __________ include deficiencies in phagocytosis, leukocyte adherence and intracellular killing, leading to increased susceptibiliy to bacterial disease.
Defects in innate immunity include deficiencies in phagocytosis, leukocyte adherence and intracellular killing, leading to increased susceptibiliy to bacterial disease.
Defects in _________ function generally predisposes an animal to overwhelming virus infections.
Defects in T cell function generally predisposes an animal to overwhelming virus infections.
Defects in _________ function and __________ production predispose an animals to overwhelming bacterial disease.
Defects in B cell function and immunoglobulin production predispose an animals to overwhelming bacterial disease.
____________ immunodeficiency are most severe since affected animals lack resistance to all infectious agents.
Combined immunodeficiency are most severe since affected animals lack resistance to all infectious agents.
Immunodeficiency
Impairment of part or parts of the immune system that renders the patient more susceptible to infectious disease
_______________ immunodificiency is charcterized by being based on mutations in a gene, inherited/congenital, occuring early in life, results in high mortality and may have mild or chronic clinical presentation.
Primary immunodificiency is charcterized by being based on mutations in a gene, inherited/congenital, occuring early in life, results in high mortality and may have mild or chronic clinical presentation.
___________ immunodeficiency is characterized by occuring more often in adult animals that previously had normal immune function.
Secondary immunodeficiency is characterized by occuring more often in adult animals that previously had normal immune function.
Age, infection, medical therapy and chronic disase are contributing factors for ______________.
Age, infection, medical therapy and chronic disase are contributing factors for secondary immunodeficiency.
Factors that contribute to primary immunodeficiency
Disease affecting a particular breed
Disease occuring in young littermate animals
Chronic recurrent infection
Infection in multiple body sites
Failure of infection to respond to standard antibiotic therapy
Infection with environmental saporphytes
Persistant lymphopenia
Failure to respond to vaccinations
Failure of ____________ results in failure of cells to differentiate and thus a decrease in production of cell types.
Failure of pluripotent stem cells results in failure of cells to differentiate and thus a decrease in production of cell types.
Failure of ______________ results in decreased or lack of production of lymphocytes.
Failure of committed stem cells results in decreased or lack of production of lymphocytes.
Failure of ____________ results in decreased immune response to foreign bodies and no production of CD4, CD8 or Tc cells.
Failure of T cell development results in decreased immune response to foreign bodies and no production of CD4, CD8 or Tc cells.
Failure of ______________ results in decreased immune respose from the host body and failure to produce selected antibodies.
Failure of B cell development results in decreased immune respose from the host body and failure to produce selected antibodies.
Failure in production of functional ____________ results in decreased immune response from the body due to decreased innate immunity
Failure in production of functional phagocytic cells results in decreased immune response from the body due to decreased innate immunity
