Autoimmunity

Question 1

_____________ cells are involved in self-reactive responses.

Answer 1

B and T cells are involved in self-reactive responses.

Question 2

Generation of T and B cell diversity receptors may be involved in an _____________ disease.

Answer 2

Generation of T and B cell diversity receptors may be involved in an autoimmune disease.

Question 3

________, ________ and ______ may be factors related to autoimmunity.

Answer 3

Sex, age and **virus **may be factors related to autoimmunity.

Question 4

Two types of autoimmunity:

Immune response to __________ antigen

Abnormal response to ________ antigen

Answer 4

Two types of autoimmunity:

Immune response to abnormal antigen

Abnormal response to normal antigen

Question 5

Autoimmune diseases can have _________ influences and __________ predispositions

Answer 5

Autoimmune diseases can have hormonal influences and genetic predispositions

Question 6

Tissue damage, molecular structural changes, newly synthesized antigena dn molecular mimicry can lead to a _______ immune response to an _________ antigen

Answer 6

Tissue damage, molecular structural changes, newly synthesized antigena dn molecular mimicry can lead to a normal immune response to an abnormal antigen

Question 7

Failure of regulatory control can lead to _________ immune response to ________ antigen.

Answer 7

Failure of regulatory control can lead to** abnormal immune response to normal** antigen.

Question 8

Virus triggered autoimmune respose via molecular mimicry:

Molecular mimicry triggered by virus → ________ is activated by APC → activated _______ has a cross reaction with _________ → autoimmune response.

Answer 8

Virus triggered autoimmune respose via molecular mimicry:

Molecular mimicry triggered by virus → resting T cell is activated by APC → activated T cell has a cross reaction with** normal tissue** → autoimmune response.

Question 9

Molecular Mimicry

Answer 9

Sharing of epitopes between an infectious agent and an autoantigen

Question 10

Virus triggered autoimmune response via bystander activation:

Bystander activation triggered by virus → T cells and APCs go though __________ → T cells are activated → autoimmune response

Answer 10

Virus triggered autoimmune response via bystander activation:

Bystander activation triggered by virus → T cells and APCs go though cytokine cascade → T cells are activated → autoimmune response