Hypersensitivity Flashcards
___________________
Allergies
Type I Hypersensitivity
Allergies
________________
Exaggerated Th2 response
Type I hypersensitivity
Exaggerated Th2 response
_________________
Excessive amounts of IgE
**Type I hypersensitivity **
Excessive amounts of IgE
Atopy
Predisposition towards developing certain allergic hypersensitivity reactions
________ and ___________ contribute to allergies.
**Genes **and environmental factors contribute to allergies.
______________ play an important role in hypersensitivity
Intestinal microflora play an important role in hypersensitivity
_____________ can cause hypersensitivity
Parasitic worms can cause hypersensitivity
Hypersensitivity
Body’s reaction towards an antigen is blown out of proportion and causes severe reactions
Hypersensitivity requires __________ state of the host
Hypersensitivity requires pre-sensitized state of the host
Type I hypersensitivity = _____________ hypersensitivity
Type I hypersensitivity =** immediate** hypersensitivity
_____________
FcER has high affinity and irreversible binding
Type I Hypersensitivity
FcER has high affinity and irreversible binding
FcER1 is present on _______, ________, _________, _________, ___________ and __________.
FcER1 is present on mast cells, basophils, neutrophils, eosinophils, dendritic cells and platelets.
FcERII is present on ______, __________, _________, ________, __________, and ___________.
FcERII is present on B cells, NK cells, macrophages, dendritic cells, eosinophils, and platelets.
FcER
Receptor that contributes to the immune system by allowing the specific cells it is found on to bind to antibodies that are attached to infected cells
Diagnosis of type I hypersensitivity by:
Intradermal skin testing
Passive cutaenous anaphylaxis
Measuring IgE concentration
Treatment of type I hypersensitivity
Avoid exposure
Corticosteroids
Antihistamines
B stimulants or alpha antagonists
Type II hypersensitivity = __________
Type II hypersensitivity = Antibody mediated cytotoxicity
Type II hypersensitivity involves ________ working as antigens
Type II hypersensitivity involves RBC working as antigens
Type III hypersensitivity = _____________
Type III hypersensitivity = Immune complex hypersensitivity
Local type of type III hypsersensitivity
immune complexes are formed within the tissue
Generalized type of type III hypersensitivity
immune complexes are formed with the blood stream and deposited in glomeruli in the kidney
Type IV hypersensitivity = _____________
Type IV hypersensitivity = Delayed type hypersensitivity (DTH)
Type IV hypersensitivity involves _____________.
Type IV hypersensitivity involves injected antigens (vaccines).
Measurement of __________ using hypersensitivity, one can separate non-dividing cells from dividing cells and be able to count the number of proliferating cells.
Measurement of proliferation using hypersensitivity, one can separate non-dividing cells from dividing cells and be able to count the number of proliferating cells.
Measurement of __________ using hypersensitivity one can measure the cells that are killed and not killed during a reaction.
Measurement of cell death using hypersensitivity one can measure the cells that are killed and not killed during a reaction.