Lymphocyte & Monocyte Disorders

Question 1

Infectious Mononucleosis

Answer 1

Caused by the Epstein-Barr virus (EBV)
Patients are positive for the heterophile antibody test
Can produce anti-i antibody that results in hemolytic anemia

Question 2

Infectious Mono Labs

Answer 2

Elevated WBC, >20% atypical lymphs
Usually >50% total lymphs
Mild thrombocytopenia
Elevated CRP/ALT/AST

Question 3

Infectious Mono Diagnosis

Answer 3

Use serological tests

VIral capsid antigen for IgM, VCA for IgG, heterophile antibodies, EBV nuclear antigen antibodies

Question 4

Infectious Lymphocytosis

Answer 4

Caused by Coxsackie virus

Elevated WBC, 60 to 95% normal mature lymphs, no atypical lymphs

Question 5

Whooping Cough

Answer 5

Caused by Bordetella pertussis infection (gram-negative coccobacillus)
WBC elevated, 70 to 90% lymphs
Small mature lymphs, some with cleaving in the nucleus