ALL

Question 1

Acute Lymphoblastic Leukemia

Answer 1

Most common form of pediatric leukemia
Symptoms include fatigue, bone pain, pallor, shortness of breath, infections, easy bruising, lymphadenopathy, and anemia
Patients present with anemia and thrombocytopenia

Question 2

ALL Risk Factors

Answer 2

Radiation exposure
Down syndrome
Fanconi's Anemia
Viral infections
EBV
Human T cell lymphoma/leukemia virus
Sibling or twin with ALL

Question 3

Precusor B Cell

Answer 3

Most common ALL
t(1;19) associated with poor prognosis
TdT positive in Pro-B and intermediate Pre-B

Question 4

Precursor T Cell

Answer 4

WBC count over 50

Lymphadenopathy and organomegaly

Question 5

Diagnosis of ALL

Answer 5

> 30% lymphoblasts
L1: lymphoblasts, common in pediatrics
L2: lymphoblasts, variable chromatin pattern, irregular shape, one or more nucleoli
L3: lymphoblasts, dark blue cytoplasm, often with vacuoles

Question 6

ALL Therapy

Answer 6

Remission induction/induction therapy
CNS prophylactic therapy
Maintenance or consolidation therapy