CLL Flashcards

1
Q

Chronic Lymphocytic Leukemia (CLL)

A

Most common adult leukemia
Characterized by numerous small, mature lymphocytes
Patient has sustained lymphocytosis and general cytopenia
Associated with Trisomy 12
See soccer ball and smudge cells

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2
Q

Hairy Cell Leukemia (HCL)

A

Presents with massive splenomegaly and pancytopenia
Bone marrow can become fibrotic and have dry tap
Fried egg appearance
TRAP stain positive

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3
Q

Multiple Myeloma

A

Presents with bone pain, fractures, hypercalcemia, renal insufficiency, anemia, bone lesions (CRAB)
Rouleaux is present due to antibodies in high concentration
Dutcher bodies, Mott cells, Bence Jones proteins
Monoclonal spike seen due to IgG antibodies

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4
Q

Lymphomas

A

Malignant accumulation of lymphocytes in the lymph nodes

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5
Q

Hodgkin’s Lymphoma

A

B cell cancer
See Reed-Sternberg cells (owl eyes)
Progresses in a predictable manner from one group of lymph nodes to the next
Very treatable
90% survival rate after 5 years of diagnosis

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6
Q

Non-Hodgkin’s Lymphomas

A

B or T cell cancers
Can arise in the lymph nodes anywhere in the body
Difficult to treat

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7
Q

Burkitt Lymphoma

A

Non-Hodgkins lymphoma composed of mature B cells
Associated with HIV and EBV infection
Biopsy shows a starry night appearance
Associated L3 lymphoblast like cells

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8
Q

Sezary Syndrome

A

Cerebriform nuclei in the peripheral blood
Present with cutaneous erythroderma and generalized lymphadenopathy
Neoplastic T cells found in lymph nodes, skin, and peripheral blood

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