CLL

Question 1

Chronic Lymphocytic Leukemia (CLL)

Answer 1

Most common adult leukemia
Characterized by numerous small, mature lymphocytes
Patient has sustained lymphocytosis and general cytopenia
Associated with Trisomy 12
See soccer ball and smudge cells

Question 2

Hairy Cell Leukemia (HCL)

Answer 2

Presents with massive splenomegaly and pancytopenia
Bone marrow can become fibrotic and have dry tap
Fried egg appearance
TRAP stain positive

Question 3

Multiple Myeloma

Answer 3

Presents with bone pain, fractures, hypercalcemia, renal insufficiency, anemia, bone lesions (CRAB)
Rouleaux is present due to antibodies in high concentration
Dutcher bodies, Mott cells, Bence Jones proteins
Monoclonal spike seen due to IgG antibodies

Question 4

Lymphomas

Answer 4

Malignant accumulation of lymphocytes in the lymph nodes

Question 5

Hodgkin’s Lymphoma

Answer 5

B cell cancer
See Reed-Sternberg cells (owl eyes)
Progresses in a predictable manner from one group of lymph nodes to the next
Very treatable
90% survival rate after 5 years of diagnosis

Question 6

Non-Hodgkin’s Lymphomas

Answer 6

B or T cell cancers
Can arise in the lymph nodes anywhere in the body
Difficult to treat

Question 7

Burkitt Lymphoma

Answer 7

Non-Hodgkins lymphoma composed of mature B cells
Associated with HIV and EBV infection
Biopsy shows a starry night appearance
Associated L3 lymphoblast like cells

Question 8

Sezary Syndrome

Answer 8

Cerebriform nuclei in the peripheral blood
Present with cutaneous erythroderma and generalized lymphadenopathy
Neoplastic T cells found in lymph nodes, skin, and peripheral blood