Hemoglobin Flashcards
1
Q
Hemoglobin Synthesis
A
Chromosome 16: 4 alpha alleles, 2 zeta
Chromosome 11: 2 beta alleles, 4 gammas (G and A), 2 deltas, 2 epsilon
2
Q
Embryonic
A
Gower 1, Gower 2, Portland
3
Q
Fetal
A
Hgb F
4
Q
Adult
A
Hgb A, Hgb A2
5
Q
Hgb A
A
Alpha and beta chains
6
Q
Hgb A2
A
Alpha and gamma chains
7
Q
Hgd C
A
Mutation of the 6th amino acid in the beta chain
Glutamate to lysine
8
Q
Hgb D
A
Mutation of amino acid 121 on the beta chain
Glutamate to glycine
9
Q
Hgb E
A
Mutation of amino acid 26 in the beta chain
Glutamate to lysine
10
Q
Hgb F
A
Fetal hgb
Alpha and gamma chains
11
Q
Hgb H
A
Beta chains
12
Q
Hgb S
A
Mutation in the 6th amino acid in the beta chain
Glutamate to valine
13
Q
Gower I
A
Zeta and epsilon chains
14
Q
Gower II
A
Alpha and epsilon chains
15
Q
Portland Hgb
A
Zeta and gamma chains
Seen in Alpha thalassemia/Hydrops fetalis
