Lymphatic System Flashcards

1
Q

The lymphatic system functions to (3)

A

1)drain interstitial fluid 2)transport dietary fats 3) carry out immune responses

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2
Q

Lymphatic capillaries merge to form BLANK which have BLANK

A

lymphatic vessels which have thin walls and many valves

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3
Q

Lymphatic vessels/lymphatics do what

A

return interstitial fluid and leaked plasma proteins back to blood

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4
Q

once interstitial fluid enters lymphatics it is called

A

lymph

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5
Q

lymphatic vessels are also called BLANK end vessels

A

dead end

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6
Q

lymphatic capilaries are made of

A

simple squamous epithelal lining

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7
Q

from lymphatic vessels, lymph passes through BLANK and then into BLANK

A

lymph nodes and then into lymph trunks

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8
Q

lymph trunks include

A

lumbar, intestinal, bronchomediastinal, subclavian and jungular trunks

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9
Q

lymph trunks merge to form

A

either the thoracic duct (left) or right lymphatic duct

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10
Q

what connects the immune system to the lymphatic system

A

lymph nodes

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11
Q

which lymph duct is larger

A

left/thoracic

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12
Q

left/thoracic duct drains

A

left upper side and both lower extremeties

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13
Q

right thoracic duct drains

A

right upper extremities and head

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14
Q

Lymph nodes serve as the

A

check point for cells and foreign invaders

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15
Q

the lymph ducts empty lymph into

A

the junction of jugular and subclavian veins of the cardiovascular system

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16
Q

afferent lymphatic vessels

A

carry lymph from capillaries to nodes

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17
Q

lymphatic capilaries

A

absorb interstitial fluid and pass lyph to afferent lymphatic vessels

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18
Q

lymph nodes do 2 things to cells

A

1) destroy cells immediately 2) take parts of foreign invaders to build army against it

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19
Q

lymph is propelled by (4)

A

skeletal muscle contraction, presure changes in thorax during breathing, valves to prevent backflow, pulsation of nearby arteries

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20
Q

primary lymphatic organs

A

1) red bone marrow 2) thymus

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21
Q

which cell stays in bone marrow

A

B cells

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22
Q

in the thymus, cells learn

A

self tolerance: not to destroy cells, immunocompetnece ability to recognize and bind to proteins - self tolerance comes before immunocompetence

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23
Q

secondary lymphatic organs and tissues

A

lymph nodes, spleen, lymphatic nodules

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24
Q

which cells migrate from the bone marrow to the thymus

A

T cells

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25
Q

where do cells become immmunocompetent

A

in the thymus

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26
Q

what happens in the spleen

A

red blood cell recycling

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27
Q

what happens in the lymphatic nodues

A

second line of defense where we filter for pathogens and screen blood

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28
Q

principal lymphoid organ of the body

A

lymph node

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29
Q

lymph nodes are embedded

A

in connective tisssue in clusters along lymphatic vessels.

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30
Q

in the lymph nodes, cell “soldiers” become

A

activated

31
Q

lymph nodes are located

A

near body surfaces in inguinal, axillary and cervical regions of the body

32
Q

in a lymph node, there is more BLANK flow than BLANK flow

A

affarent than efferent

33
Q

in a lymph node, B cells are located in

A

germinal center in secondary lymphatic nodules

34
Q

in a lymph node, T cells are located in the

A

medulla

35
Q

spleen contains

A

red pulp and white pulp

36
Q

white pulp

A

areas where lymphatic tissue, where T cells become immunocompetent

37
Q

red pulp

A

filled with sinusoidal capillaries, where red blood cells will be removed from circulation and broken down

38
Q

venous sinuses are found in

A

red pulp

39
Q

which is the largest lymphoid organ

A

spleen

40
Q

where do the splenic artery and vein enter and exit

A

hilum

41
Q

functions of spleen

A

cleanses blood of aged cells and platelets, macrophages remove debris, site of lymphocyte proliferation and immune surveillance and response

42
Q

white pulp is located

A

around central arteries- involve in immune functions

43
Q

red pulp is located

A

in venous sinuses and splenic cords

44
Q

lymphoid tissue houses and provides

A

proliferation site for lymphocytes

45
Q

lymphoid tissue is made of

A

reticular/loose connective tissue

46
Q

two types of lymphoid tissue

A

diffuse lymphoid tissue and lymphoid follicles

47
Q

lymphatic nodules are

A

masses of lymphatic tissue that are not surrounded by a capsule

48
Q

lymphatic nodules scattered throughout the lamina propri of mucous membranes lining the gastrointestinal, urinary and reproductive and respiratory airways are referred to as

A

mucosa-associated lymphatic tissue or MALT

49
Q

largest collection of MALT are located in the

A

tonsils, peyer’s patches and appendix

50
Q

peyer’s patches are located in the

A

digestive tract, mainly small intestine

51
Q

Innate Immunity

A

wide variety of body responses that serve to protect us agaisnt invasion of a wide variety of pathogens and their toxins

52
Q

which type of immunity are we born with

A

innate immunity

53
Q

two lines of defense of innate immunity

A

(external defenses) skin and mucous membranes, internal defenses

54
Q

mechanical defenses

A

skin, mucous membranes, tears, saliva, mucus, cilia, epiglottis, urine flow, defecating, vomiting

55
Q

chemical defenses

A

sebum, lysozyme, gastric juice

56
Q

internal defenses

A

antimicrobial proteins, phagocytes, natural killer cells, inflammation and fever

57
Q

adaptive immunity

A

recognizes and defeats + produces specific memory to antigens: the body’s ability to defend itself against specific invading agents

58
Q

antigens

A

substances recognized as foreing that provoke immune responses

59
Q

two types of adaptive immunity

A

cell mediated and antibody-mediated

60
Q

cell-mediated

A

intracellular- T cells includes cancerous

61
Q

antibody-mediated

A

humoral immunity- fluids B cells, extracellular immunity

62
Q

immunogenicity

A

the ability to provoke immune activation response

63
Q

reactivity

A

killing pathogens when we make T cells to attack

64
Q

entire microbes or just part of microbes may act as

A

antigens

65
Q

for an immune response to occur

A

B and T cells must recognize that a foreign antigent is present

66
Q

B cells can recognize an dbind to antigens in

A

lymph, interstitial fluid or blood plasma

67
Q

T cells only recognize

A

fragments of antigenic proteins that are processed and presented in a certain way

68
Q

epitopes

A

small parts of a large antigen molecule act as the triggers for immune response

69
Q

antigen presentation

A

during antigen processing when they are broken down into peptide fragments that associate with MHC molecules, the antigen-MHC complex is then inserted into the plasma membrane of a body cell

70
Q

which cells make MHC II

A

red blood cells, recognized by CD4

71
Q

which cells make MCH I

A

body cells, recognized my CD8

72
Q

processes in cell-mediated immunity

A

1) antigen is recognized and bound 2) a small number of T cells proliferate and differentiate into a clone of effector cells. 3)antigen is eliminated ALSO produces memory cells

73
Q

processes in antibody-mediated immunity

A

1) an antigen is recognized and bound 2)helper T cells constimulate the B cell so the B cell can proliferate and differentiate into a clone of effector cells that produce antibodies 3)antigen is eliminated

74
Q

first immunoglobulin to be secreted

A

IGM