Lupus Erythematosus

Question 1

two forms of Lupus Eryhtematosus

Answer 1

Discoid Lupus Erythematosus (DLE): only affects the skin

Systemic Lupus Erythematosus (SLE): can affect any organ or system of the body, often in different combinations (most common)

Question 2

Lupus Erythematosus

Answer 2

chronic inflammatory autoimmune disorder with highly variable clinical presentation, idiopathic

Question 3

Incidence of Lupus Eryhtematosus

Answer 3

affects females 15-40 years of age, Asian, native Americans, African Americans are 3x more likely to be diagnosed. Appears in 1st degree relatives (hereditary component)

Question 4

Pathology of Lupus Eryhtematosus

Answer 4

3 main mechanisms, autoantibody production (central immunologic disturbance, deposition of them at tissue sites suppresses normal immunity & damages tissues), inflammation, vascular abnormalities

Question 5

Clinical manifestations of Lupus Eryhtematosus

Answer 5

Neurological: TIA (transient ischemic attack), CVA (stroke), peripheral neuropathy

Question 6

Medical treatment for Lupus Eryhtematosus

Answer 6

want to control, prevent damage and flareups, NSAIDS, methotrexate (early to preserve bone & cardio protection), antimalarials (dermatological, arthritic, & renal symptoms), immune-modulating drugs, corticosteroids, cytotoxins

Question 7

Rehab management for Lupus Eryhtematosus

Answer 7

varies on nervous and musculoskeletal involvement, focus on strength, endurance, activity pacing, and energy conservation

Question 8

Special implications for the therapist dealing with Lupus Eryhtematosus

Answer 8

Following exacerbation, important to balance resumption of activity, rest periods during day and 8-10 hours of sleep. Integrate a prescriptive exercise plan, avoid excessive bed rest, and protect joints

Question 9

Prognosis of Lupus Eryhtematosus

Answer 9

no way to prevent, prognosis improves with early detection and intervention, no cure with only treatment of symptoms.

Question 10

Risk factors for Lupus Eryhtematosus

Answer 10

Immunological, environmental, hormonal & genetic factors.
 Genetic factors triggered by exogenous & endogenous
factors
 Physical & Mental stressors
 Viral Infections
 Sunlight or UV exposure
 Pregnancy(+/-), abnormal estrogen metabolism