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D&T 3 test 2 > Lung tumors and Pleura - Saroj > Flashcards

Lung tumors and Pleura - Saroj Flashcards

1
Q

what is the most common cause of cancer mortality worldwide

A

lung tumors

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2
Q

what are 3 things that can cause lung cancer

A

tobacco smoking
industrial hazards
air pollutoin

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3
Q

What is the most common cancer for malignancy for asbestosis

A

bronchogenic carcinoma or lung cancer

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4
Q

Female, asian, 40 yr old, nonsmoker, with lung history will likely show what mutation? with adenocarcinomas

A

EGFR

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5
Q

what are 4 precursor lesions for lung tumors

A
  1. squamous dysplasia/ Carcinoma in situ
  2. atypical adenomatous hyperplasia
  3. adenocarcinoma in-situ
  4. neuroendocrine cell hyperplasia
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6
Q

what type of lung cancer is a candidate for surgery

A

non-small cell carcinoma

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7
Q

how do you treat small cell carcinoma

A

chemotherapy

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8
Q

Name 2 types of non-small cell carcinoma

A
  1. squamous cell carcinoma

2. adenocarcinoma

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9
Q

which lung cancer is almost always metastatic

A

small cell

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10
Q

what type of lung cancer is associated with smoking

A

squamous

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11
Q

location of squamous cell carcinoma

A

centrally located

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12
Q

mutation related to squamous cell carcinoma

A

p53 mutation

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13
Q

what would be a blood value for squamous cell carcinoma

A

hypercalcemia

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14
Q

histo, well-differentiated squamous cell carcinoma

A

keratinization/squamous pearls

intercellular bridges

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15
Q

histo, poorly differentiated squamous cell carcinoma

A

increased mitotic activity

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16
Q

patient smokes, central necrosis, increase Ca levels, biopsy shows squamous pearl, intercellular bridging. would you perform surgery?

A

yes

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17
Q

squamous cell amplifies what gene

A

FGFR1

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18
Q

what is most common lung cancer in women

A

adenocarcinoma

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19
Q

location of adenocarcinoma in lung

A

peripheral bronchioloalveolar regions

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20
Q

does adenocarcinoma in-situ invade

A

no invasion, lines alveolar

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21
Q

Another name for adenocarcinoma in-situ

A

Bronchioloaleolar carcinoma BAC

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22
Q

adenocarcinoma is positive for what in immunohistochemical stain

A

TTF-1 positive

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23
Q

histo for adenocarcinoma in-situ

A

lepidic growth pattern

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24
Q

how can adenocarcinoma in-situ present clinically sometimes

A

pneumonia-like

25
Q

what type of cells are in adenocarcinoma in-situ mucinous

A

tall columnar cells with intracytoplasmic mucin

26
Q

what type of cells are in adenocarcinoma in-situ non-mucinous

A

cuboidal cells

27
Q

which type of adenocarcinoma in situ spreads aerogenously with satellite lesions

A

mucinous

28
Q

what type of adenocarcinoma in situ has better prognosis

A

non-mucinous

29
Q

Adenocarcinoma, NONSMOKER , female will have a gain of function mutation in what tyrsosine kinase mutation

A

EGFR

30
Q

Adenocarcinoma, SMOKER female will have a gain of function mutation in what non tyrsosine kinase mutation

A

KRAS

31
Q

what type of tumor is neuroendocrine proliferations and tumors

A

non-small

32
Q

what are important features for neuroendocrine proliferations and tumors

A

mitotic figures

necrosis

33
Q

histo for small cell carcinoma

A
  • Azzopardi effect: basophillic staining
  • high mitotic count
  • cell necrosis
  • nuclear molding
  • ill defined cells
34
Q

what do granules look like on EM for small cell carcinoma

A

dense core

35
Q

histo for carcinoid tumor

A
  • organoid pattern
  • small rounded uniform nuclei
  • moderate cytoplasm
36
Q

what makes up a Hamartoma

A

stromal and epithelial components

  • cartilage and columnar epithelium
  • coin lesion
37
Q

who gets lymphanioleiomyomatosis

A

young women of childbearing age

38
Q

what is lymphanioleiomyomatosis

A

proliferation of perivascular epithelioid cells

39
Q

what is lymphanioleiomyomatosis positive for

A

melanocytic marker
smooth muscle marker
suppressor TSC 2

40
Q

Inflammatory myofibroblastic tumor

A

inflammatory pseudotmor/plasma cell granuloma

41
Q

who gets Inflammatory myofibroblastic tumor

A

children and young adults

42
Q

what is the common metastasis place for lung cancer

A

adrenal

43
Q

what are 3 lung cancer syndromes

A

Lambert-Eaton myasthenic syndrome
Superior vena cava syndrome
Horner’s syndrome

44
Q

what is Lambert-Eaton myasthenic syndrome

A

weakness of proximal legs and arms

45
Q

what can Superior vena cava syndrome cause

A

circulatory compromise

46
Q

name primary tumor pleura

A

solitary fibrous tumor

47
Q

solitary fibrous tumor invlves what pleura

A

viscerla

48
Q

solitary fibrous tumor benign or malignant

A

benign

49
Q

Gross solitary fibrous tumor

A

dense fibrous tissue

- sometimes cysts

50
Q

microscopic solitary fibrous tumor

A

whorls of reticulin and collagen

interspersed spindle cells

51
Q

solitary fibrous tumor stains for

A

CD34 positive

Keratine negative

52
Q

solitary fibrous tumor relationship with asbestosi

A

no

53
Q

clinical presentation for malignant mesothelioma

A

unilateral chest pain

flu-like

54
Q

what is malignant mesothelioma assoicated and not associated with

A

associated with asbestois

not with smoking

55
Q

histo for malignant mesothelioma

A

gra-white nodules

56
Q

histo subtypes for malignant mesothelioma

A
  • epitheliod

- sarcomatoid

57
Q

malignant mesothelioma , IHC stains for

A

Calretinin
WT-1
CK5/6
D2-40

58
Q

malignant mesothelioma Em shows

A

long microvilli

D&T 3 test 2 (14 decks)

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