Fenger Flashcards
What is usually not involved with parainfluenza virus and influenza virus
viremia
how long is incubation period for respiratory viruses
short
1-3 days
What if the virus causes a viremia, how long is incubation period
longer
weeks to weeks
What is the genomic make up for paramyxovirdiae
SS RNA
negative polarity
nonsegmeted
What structures does paramyxovirdiae have
Helical nucleocapsid
RNA dependent RNA polymerase
envelope
6 structural proteins
Name some glycoprotiens in paramyxovirdiae
Hemagglutinin (H) and Neruminadase (N)
What are the 3 primary genera for paramyxovirdiae
- paramyxovirus
- morbillivirus
- pneumovirus
How do the genera of paramyxovirdiae differe
differe in envelope glycoproteins
function of H glycoprotein
attachment of virus to receptors on cell surface
function of F glycoprotein
mediates fusion between viral envelope and outer cell membrane
what must happen to F glycoprotein in order for it to work
- proteolytically cleaved on viral envelope surface
F glycoprotein is similar to what
H glycoprotein of influenza virus
Where does Paramyxoviridae virus repliacate
cytoplasm
Paramyxovirus genus: type 1 symptoms
croup acute respiratory disease pneumonitis of newborns colds in adults coryza pharyngitis bronchitis children - bronchiolitis
Paramyxovirus genus: type 2 symptoms
coup
laryngotracheobronchitis
Paramyxovirus genus: type 3 and 4 symptoms
acute respiratory disease
bronchitis
pneumonia
Paramyxovirus genus has what disease
measles ( roseola)
what is under pneumovirus genus
RSV
what is the virulence factor for RSV
F glycoprotein
clinical symptoms of RSV
bronchiolitis and pneumonia in infants
what is the immune defense for RSV? what is not a good immune response
IgA
- maternal antibody IgG does not protect, may actually enhance severity
What do you give to babies at risk for RSV
- Palivizumab
- IV prophylaxis
which picornaviridae virus is acid stable and which ones are not
- enterovrises: acid stable
- rhinovirus is not
Enterovirus is commonly seen in who
young individuals
immunocompromised
How are HSV-1 gingtivostomatitis lesions seen
throughout oral cavity
symptoms of Coxsackievirus group A
- hand, foot, mouth
- cold virus
- aseptic meningitis
how many types of Coxsackie group B are there
6
As in the case with other coxsackie viruses, the serotypes that cause coxsackie group B begin with?
respiratory infection
clinical manifestation for Coxsackie group B
COLDS
summer grippe
What are clinical features of Echovirus
- summer aseptic meningitis
- febrile illnes with rash ( young people)
type D68 of new enteroviruses causes what? who is it seen in
respiratory illness
- more severe in children and asthmatics
what is rhinovirus hard to distinguish from
H1N1
what is the viral structure of Coronaviridae
- helical nucleocapsid
- positivve RNA
Coronaviridae: coronavirus most common assoicated
SARS - group 2
clinical feature of coronavirus? when does this usually occur
infectious bronchitis in adults
winter or early spring
- cold symptoms
symptoms of SARS
high fever
cough
SOB
what does SARS bind
- cell receptors
2. ACE 2 on epithelial cells
What types of adenovirus is associated with military recruits
4,7,21
8
Adenovirus has what 2 components
240 hexons
12 pentons
what do hexons connect?
contact with 6 neighboring capsomers
- each has small hole in the center
Location of pentons? what do pentons connect
- vertices of icosahedron
- contact with 5 neighboring capsomers
- each has small hole in the center
What does penton consist of
base
fiber
knob at distal end of fiber
where does adenovirus replicate
host cell nucleus
adenovirus produces what type of infection in tonsil, adenoids and other lymph organs in children
latent
for adenovirus replication what early proteins are enzymes involved with DNA synthesis
thymidine kinase
DNA polymerase
where does replication and viral assembly occur for adenovirus
nucleus
-grapelike cluster of virus particles
What are the two important adenovirus types
4 and 7
adenoviurs Type 7 and 3 have what clinical feature
pneumonia in children
Adenoviurs types 8,7,19 have what clinical features
keratoconjunctivitis
shipyard conjunctivitis
what type of vaccine is used for what serotype for adenovirus
live oral vaccine for type 4 and 7
how does an oral, live-attenuated vaccine prevent respiratory disease
- increase IgG
- IgG indirectly impacts respiratory
