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D&T 3 test 2 > Fenger > Flashcards

Fenger Flashcards

1
Q

What is usually not involved with parainfluenza virus and influenza virus

A

viremia

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2
Q

how long is incubation period for respiratory viruses

A

short

1-3 days

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3
Q

What if the virus causes a viremia, how long is incubation period

A

longer

weeks to weeks

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4
Q

What is the genomic make up for paramyxovirdiae

A

SS RNA
negative polarity
nonsegmeted

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5
Q

What structures does paramyxovirdiae have

A

Helical nucleocapsid
RNA dependent RNA polymerase
envelope
6 structural proteins

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6
Q

Name some glycoprotiens in paramyxovirdiae

A

Hemagglutinin (H) and Neruminadase (N)

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7
Q

What are the 3 primary genera for paramyxovirdiae

A
  1. paramyxovirus
  2. morbillivirus
  3. pneumovirus
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8
Q

How do the genera of paramyxovirdiae differe

A

differe in envelope glycoproteins

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9
Q

function of H glycoprotein

A

attachment of virus to receptors on cell surface

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10
Q

function of F glycoprotein

A

mediates fusion between viral envelope and outer cell membrane

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11
Q

what must happen to F glycoprotein in order for it to work

A
  • proteolytically cleaved on viral envelope surface
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12
Q

F glycoprotein is similar to what

A

H glycoprotein of influenza virus

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13
Q

Where does Paramyxoviridae virus repliacate

A

cytoplasm

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14
Q

Paramyxovirus genus: type 1 symptoms

A 
croup 
acute respiratory disease
pneumonitis of newborns 
colds in adults
coryza
pharyngitis
bronchitis
children - bronchiolitis
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15
Q

Paramyxovirus genus: type 2 symptoms

A

coup

laryngotracheobronchitis

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16
Q

Paramyxovirus genus: type 3 and 4 symptoms

A

acute respiratory disease
bronchitis
pneumonia

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17
Q

Paramyxovirus genus has what disease

A

measles ( roseola)

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18
Q

what is under pneumovirus genus

A

RSV

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19
Q

what is the virulence factor for RSV

A

F glycoprotein

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20
Q

clinical symptoms of RSV

A

bronchiolitis and pneumonia in infants

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21
Q

what is the immune defense for RSV? what is not a good immune response

A

IgA

- maternal antibody IgG does not protect, may actually enhance severity

22
Q

What do you give to babies at risk for RSV

A
  • Palivizumab

- IV prophylaxis

23
Q

which picornaviridae virus is acid stable and which ones are not

A
  • enterovrises: acid stable

- rhinovirus is not

24
Q

Enterovirus is commonly seen in who

A

young individuals

immunocompromised

25
Q

How are HSV-1 gingtivostomatitis lesions seen

A

throughout oral cavity

26
Q

symptoms of Coxsackievirus group A

A
  • hand, foot, mouth
  • cold virus
  • aseptic meningitis
27
Q

how many types of Coxsackie group B are there

A

6

28
Q

As in the case with other coxsackie viruses, the serotypes that cause coxsackie group B begin with?

A

respiratory infection

29
Q

clinical manifestation for Coxsackie group B

A

COLDS

summer grippe

30
Q

What are clinical features of Echovirus

A
  • summer aseptic meningitis

- febrile illnes with rash ( young people)

31
Q

type D68 of new enteroviruses causes what? who is it seen in

A

respiratory illness

- more severe in children and asthmatics

32
Q

what is rhinovirus hard to distinguish from

A

H1N1

33
Q

what is the viral structure of Coronaviridae

A
  • helical nucleocapsid

- positivve RNA

34
Q

Coronaviridae: coronavirus most common assoicated

A

SARS - group 2

35
Q

clinical feature of coronavirus? when does this usually occur

A

infectious bronchitis in adults
winter or early spring

  • cold symptoms
36
Q

symptoms of SARS

A

high fever
cough
SOB

37
Q

what does SARS bind

A
  1. cell receptors

2. ACE 2 on epithelial cells

38
Q

What types of adenovirus is associated with military recruits

A

4,7,21

8

39
Q

Adenovirus has what 2 components

A

240 hexons

12 pentons

40
Q

what do hexons connect?

A

contact with 6 neighboring capsomers

- each has small hole in the center

41
Q

Location of pentons? what do pentons connect

A
  • vertices of icosahedron
  • contact with 5 neighboring capsomers
  • each has small hole in the center
42
Q

What does penton consist of

A

base
fiber
knob at distal end of fiber

43
Q

where does adenovirus replicate

A

host cell nucleus

44
Q

adenovirus produces what type of infection in tonsil, adenoids and other lymph organs in children

A

latent

45
Q

for adenovirus replication what early proteins are enzymes involved with DNA synthesis

A

thymidine kinase

DNA polymerase

46
Q

where does replication and viral assembly occur for adenovirus

A

nucleus

-grapelike cluster of virus particles

47
Q

What are the two important adenovirus types

A

4 and 7

48
Q

adenoviurs Type 7 and 3 have what clinical feature

A

pneumonia in children

49
Q

Adenoviurs types 8,7,19 have what clinical features

A

keratoconjunctivitis

shipyard conjunctivitis

50
Q

what type of vaccine is used for what serotype for adenovirus

A

live oral vaccine for type 4 and 7

51
Q

how does an oral, live-attenuated vaccine prevent respiratory disease

A
  • increase IgG

- IgG indirectly impacts respiratory

D&T 3 test 2 (14 decks)

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