Lung Cancer Pathology

Question 1

What carcinogenic pathway occurs in the periphery of the lung?

Answer 1

Bronchiolveolar stem cells transform leading to adénocarcinome

Question 2

What carcinogenic pathway occurs in the central airways?

Answer 2

Bronchial epithelial stem cells transform leading to squamous cell carcinoma

Question 3

What proportion of lung cancers are small cell?

Answer 3

15%

Question 4

What are the local effects of lung cancer?

Answer 4

Bronchial obstruction:
-collapse
-pneumonia
-infection/abscess
-bronchiectasis

Pleural
-inflammation
-malignancy

Invasion of chest wall
Nerves (l recurrent pharyngeal, phrenic, brachial plexus, cervical sympathetic causing horners syndrome)

Question 5

Which bio markers are suitable for immunotherapy?

Answer 5

EGFR, KRAF, HER2, BRAF