LT11 - General porinciples: molecular diagnostics Flashcards
1
Q
Different types of point mutations
A
- Missence mutation
- Nonsens mutation
- Silent mutation
- Frameshift mutation
2
Q
structure of (solid) tumors
A
- lymphocytes in between the tumor mass
- stromal cells present
3
Q
BRAF inhibitors
A
- dabrafenib
- vemurafenib
4
Q
Development lung cancer
A
EGFR mutation –> phosphorylation –> activation of PI3K or KRAS pathway –> development of lungcancer
5
Q
Function tyrosine kinase inhibitors
A
inhibit EGFR pathway
6
Q
Therapy for lungcancer with an EGFR mutation
A
osimertinib
7
Q
HER2 amplification leads to
A
breast cancer
8
Q
ALK translocation leads to
A
Lung cancer
9
Q
NTRK fusions
A
rare but in all solid tumors
