Lower GI Bacterial Toxins

Question 0

Has an emetic, preformed enterotoxin that produces holes in membranes

Answer 0

Bacillus cereus

Question 1

Has 7 different toxins that survive at high temps

Answer 1

Staph aureus

Question 2

Has a diarrheal Ig molecular weight enterotoxin that is present if infection is in large amounts in small intestine

Answer 2

Bacillus cereus

Question 3

Has a powerful neurotoxin blocking ACh release from motor end plates

Answer 3

Clostridium botulinum

Question 4

Has an enterotoxin that binds into endothelial cell junctions, making pores

Answer 4

Clostridium perfringens

Question 5

Replicates in host cell and increases water and electrolyte secretion into the lumen

Answer 5

Salmonella spp

Question 6

Invasive into immune cells, spreads to other organs. Uses actin polymerization to move in the cell

Answer 6

Listeria monocytogenes

Question 7

Enterotoxins include TDH (thermostable direct hemolysin) and TRH.

Answer 7

Vibrio parahaemolyticus

Question 8

Enters M cell to be taken up by a macrophage, leading to inflammation. Uses actin rockets.

Answer 8

Shigella sonei and flexnori

Question 9

Invasive, phage-borne shiga toxin which acts on vascular endothelial cells inactivating ribosomes and causing cell death

Answer 9

Shigella dysenteriae

Question 10

Has a toxin that activates adenylate cyclase, increasing CFTR and water, with no bacterial penetration

Answer 10

ETEC, Vibrio cholerae

Question 11

Has a toxin that causes intimate attachment to a cell with actin condensation and microvillous effacement

Answer 11

EHEC

Question 12

Has exotoxins leading to cell death. Early lesions are superficial, then ulcers, then pseudomembranes

Answer 12

C. diff