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Paediatrics > Liver Problems COPY > Flashcards

Liver Problems COPY Flashcards

1
Q

What are the functions of the liver?

A
  • Produces essential proteins including albumin and clotting factor
  • Absorption and metabolism of fat, carbahydrate and protein
  • Storage of glycogen, vitamins and minerals
  • Metabolism and excretion of toxic products in the body
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2
Q

What is included in LFTs

A
  • Bilirubin (total and split)
  • ALT/AST
  • Alkaline phosphatase
  • Gamma glutamyl transferase (GGT)
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3
Q

When is ALT/AST elevated?

A

In hepatocellular damage (hepatitis)

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4
Q

When are alkaline phosphatase and GGT elevated?

A

Biliary disease

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5
Q

What tests are used to assess the function of the liver?

A
  • Coagualtion - best test for liver function
    • prothrombin time (PT) / INR
    • APTT
  • Albumin
  • Bilirubin
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6
Q

How can paediatric liver disease manifest?

A
  • Jaundicece - usually most obvious in sclera
  • Incidental finding of abnormal blood test
  • Symptoms/signs of chronic liver disease
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7
Q

What are the signs of chronic liver disease in children?

A
  • Encephalopathy
  • Jaundice
  • Cholestasis
  • Ascites
  • Rickets secondary to vit D deficiency
  • Varices with portal hypertension
  • Spleomegaly
  • Finger clubbing
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8
Q

What is jaundice?

A
  • Yellow discolouration of skin and tissues due to accumulation of bilirubin
    • Usually most obvious in sclera
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9
Q

When is jaundice usually visible?

A

Total bilirubin >40-50 micromol/l

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10
Q

What is infant jaundice classification dependent on?

A
  • Bilirubin metabolism
    • Pre-hepatic, hepatic, post hepatic
  • Age
    • Early (<24 hours), Intermediate (24 hours to 2 weeks), Prolonged (>2 weeks)
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11
Q

What is the solubility of conjugated and unconjugated bilirubin?

A
  • Water soluble
  • Fat insoluble
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12
Q

When does pre-hepatic jaundice occur?

A

Excess of unconjugated birlirubin

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13
Q

When does intrahepatic jaundice occur?

A

-Excess of conjugated and unconjugated bilirubin jaundice due to issue within the liver

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14
Q

When does post-hepatic jaundice occur?

A

Excess of conjugated bilirubin normally due obstruction

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15
Q

What is early neonatal jaundice?

A

-<24 hours old -ALWAYS PATHOLOGICAL

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16
Q

What can cause early neonatal jaundice?

A

-Haemolysis -Sepsis

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17
Q

What is intermediate neonatal jaundice?

A

Occurs between 24hours and 2 weeks of age

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18
Q

What can cause intermediate neonatal jaundice?

A

-Physiological -Breast milk -Sepsis -Haemolysis

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19
Q

What is prolonged neonatal jaundice?

A

Occurs after 2 weeks of age

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20
Q

What can cause prolonged neonatal jaundice?

A

-Extrahepatic obstruction -Neonatal hepatitis -Hypothyroidism -Breast milk

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21
Q

Why does physiological jaundice occur?

A

-Shorter RBC life span in infants (80-90 days) -Relative polycythaemia -Relative immaturity of liver function

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22
Q

What type of jaundice is physiological jaundice?

A

Unconjugated

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23
Q

When does physiological jaundice occur?

A

After the 1st day of life as it takes time for RBC to break down

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24
Q

Why does jaundice occur with breast fed babies?

A

-Exact reason for prolongation of jaundice in breastfed infants unclear -Inhibition of UDP by progesterone metabolite? -Increased enterohepatic circulation?

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25
Q

What type of jaundice is breast milk jaundice?

A

Unconjugated

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26
Q

How long can breast milk jaundice persist?

A

Up to 12 weeks from birth

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27
Q

Apart from breast milk and physiological what other causes of unconjugated infant jaundice are there?

A

-Sepsis -Haemolysis (excessive) -Abnormal conjugation

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28
Q

Why might there be excessive haemolysis in a baby leading to jaundice?

A

-ABO incompatibility -Rhesus disease -Bruising/cephalhaematoma -Red cell membrane defects (e.g. spherocytosis) -Red cell enzyme defects (e.g. G6PD)

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29
Q

What causes of abnormal conjugation are there?

A

-Gilbert’s disease (common, mild) -Crigler-Najjar syndrome (very rare but sever)

30
Q

What investigation would you do for sepsis causing jaundice?

A

-Urine culture -Blood culture -TORCH screen

31
Q

What investigation would you do for ABO incompatibility causing jaundice?

A

-Blood group -DCT

32
Q

What investigation would you do for Rhesus disease causing jaundice?

A

-Blood group -DCT

33
Q

What investigation would you do for bruising/cephalhaematoma causing jaundice?

A

Clinical examination

34
Q

What investigation would you do for red cell membrane defects causing jaundice?

A

Blood film

35
Q

What investigation would you do for red cell enzyme defects causing jaundice?

A

G6PD assay

36
Q

What investigation would you do for Gilbert’s disease causing jaundice?

A

Genotype/phenotype

37
Q

What investigation would you do for Crigler-Najjar syndorme causing jaundice?

A

Genotype/phenotype

38
Q

What is a possible complication of unconjugated jaundice?

A

Kernicterus

39
Q

Why does kernicterus occur?

A

-Unconjugated bilirubin is fat-soluble (water insoluble) so can cross blood-brain barrier -It is neurotoxic and deposits in brain (particularly the basal ganglia)

40
Q

What are the early signs of kernicterus?

A

-Encephalopathy -Poor feeding -Lethargy -Seizures

41
Q

What are the late signs of kernicterus?

A

-Severe choreoathetoid cerebral palsy -Learning difficulties -Sensorineural deafness

42
Q

How is unconjugated jaundice treated?

A

Phototherapy -Visible light (450nm wavelength) (not UV) converts bilirubin to water soluble isomer (photoisomerisation) -Threshold for phototherapy in infants guided by charts

43
Q

What is prolonged infant jaundice?

A

Jaundice persisting beyond 2 weeks of life or 3 weeks of life in preterms

44
Q

What are the conjugated causes of prolonged infant jaundice?

A

-Anatomical (biliary obstruction) -Neonatal hepatitis

45
Q

What are the unconjugated causes of prolonged infant jaundice?

A

-Hypothyroidism -Breast-milk jaundice

46
Q

What causes of biliary obstruction can lead to prolonged jaundice?

A

-Biliary atresia -Choledochal cyst -Alagille syndrome

47
Q

What is biliary atresia characterised by?

A

Conjugated jaundice with pale stools

48
Q

What is choledochal cyst characterised by?

A

Conjugated jaundice with pale stools

49
Q

What is Alagille syndrome characterised by?

A

-Intrahepatic cholestasis -Dysmorphism -Congenital cardiac disease

50
Q

What is biliary atresia?

A

Congenital fibro-inflammatory disease of the bile ducts leading to destruction of extra-hepatic bile ducts

51
Q

How does biliary atresia present?

A

-Prolonged conjugated jaundice -Pale stools and dark urine

52
Q

What can biliary atresia progress to?

A

Liver failure if not identified and treated (can occur within months of life)

53
Q

What is the most common indication for liver transplant in children?

A

Biliary atresia

54
Q

What is the treatment for biliary atresia?

A

Kasai portoenterostomy -Success rate diminishes rapidly with age -Best results if performed before 60 days (<9 weeks) -Small bowel divided and extrahepatic ducts removed. Liver bile ducts plugged directly into the small bowel

55
Q

What investigations are done for biliary atresia?

A

-Split bilirubin -Stool colour -Ultrasound -liver biopsy

56
Q

What investigations are done fro choledochal cyst?

A

-Split bilirubin -Stool colour -Ultrasound

57
Q

What investigations are done for Alagille syndrome?

A

-Dysmorphism -Genotype

58
Q

What causes of neonatal hepatitis are there?

A

-Alpha-1-antitrypsin deficiency -Galactosaemia -Tyrosinaemia -Urea cycle defects -Haemochromatosis -Glycogen storage disorders -Hypothyroidism -Viral hepatitis -Parenteral nutrition

59
Q

How is alpha-1 antitrypsin deficiency investigated?

A

Phenotype/level

60
Q

How is galactosaemia investigated?

A

GAL-1-PUT

61
Q

How is tyrosinaemia investigated?

A

Amino acid profile

62
Q

How are urea cycle defects investigated?

A

Ammonia levels

63
Q

How is haemochromotosis investigated?

A

-Iron studies -Liver biopsy

64
Q

How are glycogen storage disorders investigated?

A

Biopsy

65
Q

How is hypothyroidism investigated?

A

TFTs

66
Q

How is viral hepatitis investigated?

A

-Serology -PCR

67
Q

How is parenteral nutrition investigated?

A

History

68
Q

What should you always ask about with prolonged infant jaundice?

A

Stool colour

69
Q

What is the most important test fro prolonged infant jaundice?

A

Split bilirubin to determine if it is conjugated or unconjugated in nature

70
Q

What is the main diagnosis to exclude with conjugate prolonged jaundice?

A

Biliary atresia

Paediatrics (38 decks)

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